purpose: to report the histopathological diagnoses of recipient corneal buttons in patients undergoing penetrating keratoplasty. methods: in this observational case series, all recipient corneal specimens sent to the ophthalmic pathology laboratory of the eye bank of iran between 2004 and 2007 underwent histopathologic examination. results: overall, 315 corneal specimens were evaluated. histopa...

LABORATORY DATA chromosomal assignment chromosome 5q localization gene, structural-functional anomalies gene analysis-DNA analysis TGFBI (CSD2) (CDGG1) (CSD) (BIGH3) transforming growth factor, beta-induced 68kD, gene chr.5q31 OCULAR DISORDERS corneal defects not including dystrophy isolated ocular defects: corneal dystrophy, isolated defects corneal dystrophy, isolated defect corneal dystrophy...

The hereditary Thiel-Behnke corneal dystrophy, first described in 1967, is frequently confused with Reis-Bucklers dystrophy. Both conditions affect Bowman’s layer and can be difficult to differentiate both clinically and histopathologically. Previously, electron microscopic studies of corneal dystrophies affecting Bowman’s layer identified characteristic ‘‘curly fibres,’’ but it was unclear whe...

purpose: to report the confocal scan features in a case with clinical diagnosis of meesmann corneal dystrophy (mcd). case report: a 17-year-old female with recurrent episodes of corneal erosion and a clinical diagnosis of mcd underwent in vivo confocal scanning of both corneas. the confocal scan features included hyporeflective round-shaped areas measuring 6.8 to 41.4 mm within the superficial ...

PURPOSE Low intraocular pressure (IOP) measured by Goldmann applanation tonometry (GAT) is one of the ocular manifestations of Steinert's myotonic dystrophy. The goal of this study was to evaluate the corneal-compensated IOP as well as corneal properties (central corneal thickness and corneal hysteresis) in patients with myotonic dystrophy. METHODS A total of 12 eyes of 6 patients with Steine...

PURPOSE To determine the extracellular matrix proteins involved in the formation of human granular and lattice type I corneal stromal dystrophies, the expression patterns of fibrillin-2, tenascin-C, matrilin-2, and matrilin-4 were compared in human corneal stromal dystrophy samples. METHODS Ten cases of granular dystrophy, 7 cases of lattice dystrophy, and 6 normal corneal buttons collected d...

PURPOSE To describe the morphologic features of Fuchs corneal dystrophy and compare them with those of bullous keratopathy. METHODS This was an observational case series. The study group consisted of 32 corneal buttons with a diagnosis of Fuchs dystrophy and the comparison group consisted of 22 corneal buttons with bullous keratopathy. Morphologic analysis was performed of corneal buttons fro...

IN the complete form of this familial syndrome males suffer from corneal dystrophy, congenital ichthyosis (ichthyosis simplex), and allergic manifestations such as asthma and hay fever. The complete syndrome was noted in two patients. Other male members had corneal dystrophy and allergy, corneal dystrophy and ichthyosis, ichthyosis alone, ichthyosis and allergy, or asthma (Fig. 1). Except for t...

The purpose of present study is to discuss the clinical findings and management options of posterior polymorphous corneal dystrophy and to review the current literature on this rare entity. We report a case of asymptomatic posterior polymorphous corneal dystrophy. Posterior polymorphous corneal dystrophy is a rare, familial clinical entity with subtle findings that are important to recognize, a...

Alport Syndrome is a hereditary disease that is caused by a gene mutation and affects the production of collagen in basement membranes; this condition causes hemorrhagic nephritis associated with deafness and ocular changes. The X-linked form of this disease is the most common and mainly affects males. Typical ocular findings are dot-and-fleck retinopathy, anterior lenticonus, and posterior pol...