The absence of TSH-stimulated radioiodide uptake in differentiated thyroid cancer is associated with a high recurrence rate and reduced survival. We studied regulation of the sodium/iodide symporter gene in human papillary thyroid cancer cell lines (BHP) and primary human thyroid cells. BHP cells expressed very low levels of sodium/iodide symporter mRNA and did not concentrate iodide, but iodid...

Previous studies have demonstrated that short-term oral iodide administration, in doses ranging from 1500 micrograms to 250 mg/day, has an inhibitory effect on thyroid hormone secretion in normal men. As iodide intake in the USA may be as high as 800 micrograms/d, we investigated the effects of very low dose iodide supplementation on thyroid function. Thirty normal men aged 22-40 years were ran...

introduction: effective debridement of the root canal system with chemical irrigants prior to obturation is the key to long-term success of endodontic therapy. the purpose of this study is to compare the antibacterial activity of 2.5% sodium hypochlorite (naocl) and 2% iodine potassium iodide (iki) solutions as intracanal disinfectant in infected root canals during one-visit endodontic treatmen...

an experiment was conducted to investigate the effect of thyroid gland activity modulation (hyper or hypothyroidism) on energy utilization in broiler chickens. two hundred and forty one-day-old cobb broiler chicks were distributed into three dietary metabolizable energy (me) treatment groups (80 chicks each). the control group (e0) was fed basal diet (3150 kcal/kg diet), the second group (e1) w...

Thyroid hormones are essential for normal development and metabolism. Thyroid hormone biosynthesis requires iodide uptake into the thyrocytes and efflux into the follicular lumen, where it is organified on selected tyrosyls of thyroglobulin. Uptake of iodide into the thyrocytes is mediated by an intrinsic membrane glycoprotein, the sodium-iodide symporter (NIS), which actively cotransports two ...

The regulation of thyroid metabolism by iodide involves numerous inhibitory effects. However, in unstimulated dog thyroid slices, a small inconstant stimulatory effect of iodide on H(2)O(2) generation is observed. The only other stimulatory effect reported with iodide is on [1-(14)C]glucose oxidation, i.e., on the pentose phosphate pathway. Because we have recently demonstrated that the pentose...

In a preceding report, we showed evidence that thyrotropin (TSH) stimulates Ca2+ efflux from mouse thyroid gland and that TSH stimulation of Ca2+ efflux is inhibited by acute administration of excess iodide to mice fed a low iodine diet (Hashizume et al., 1984). The observations suggested that iodide inhibits Ca2+ efflux through an inhibition of TSH-sensitive adenylate cyclase activity. We foun...

sodium iodide-131 is administrated for treatment of hyperthyroidism and thyroid cancer. iodine-131 has multiple routs of excretion (urine, saliva, sweat, milk, feces, exhalation) from the body. patients receiving sodium iodide-131 therapy exposes other persons and the environment to unwanted radiation and contamination. the major source of radiation dose from administration of iodine-131 is ext...

Several apical iodide translocation pathways have been proposed for iodide efflux out of thyroid follicular cells, including a pathway mediated by the sodium-coupled monocarboxylate transporter 1 (SMCT1), which remains controversial. Herein, we evaluate structural and functional similarities between SMCT1 and the well-studied sodium-iodide symporter (NIS) that mediates the first step of iodide ...