Copper-64 (T(1/2) = 12.7 hours; beta(+), 0.653 MeV [17.8 %]; beta(-), 0.579 MeV [38.4 %]) has decay characteristics that allow for positron emission tomography (PET) imaging and targeted radiotherapy of cancer. The well-established coordination chemistry of copper allows for its reaction with a wide variety of chelator systems that can potentially be linked to peptides and other biologically re...

introduction: 64cu-pyruvaldehyde-bis(n4-methylthiosemicarbazone) (64cu-ptsm)‍ is one of the most important copper radiopharmaceuticals used in clinical experiments. methods: in this work, copper-64 (t1/2=12.33 h) production has been presented followed by the synthesis of the complexing agent, ptsm, and its structure was confirmed by common spectroscopic methods followed by radiolabeling with 64...

Introduction: 64Cu-pyruvaldehyde-bis(N4-methylthiosemicarbazone) (64Cu-PTSM)‍ is one of the most important copper radiopharmaceuticals used in clinical experiments. Methods: In this work, copper-64 (T1/2=12.33 h) production has been presented followed by the synthesis of the complexing agent, PTSM, and its structure was confirmed by common spectroscopic methods followed by radiolabeling w...

Copper-64 (T(1/2) = 12.7 h; beta(+): 17.8%, beta(-): 41%) has applications in both positron emission tomography (PET) imaging and targeted radiotherapy of cancer. Copper-64 radiopharmaceuticals have shown tumor growth inhibition with a relatively low radiation dose in animal models; however, the mechanism of cytotoxicity has not been fully elucidated. Here, we report an investigation on the pot...

background: copper-64 (t1/2=12.7 h) is an important radionuclide used both in pet imaging and therapy. [64cu]-pyruvaldehyde-bis (n4-methylthiosemicarbazone) ([64cu]-ptsm) is one of the most famous copper radiopharmaceuticals with unique specifications (suitable half life, stability, etc.). the wide range of 64cu applications arouse great interest for its production. materials and methods: cu-64...

Materials, known as radiopharmaceuticals, are intro.The use of specific radiotracers called radiopharmaceuticals for imaging organ function and disease states is a unique capability of nuclear medicine.nuclear medicine. The manual describes the requirements for safe preparation and quality control of radiopharmaceuticals. In addition, it contains essential.important factors common to most nucle...

Copper-64 (T(1/2) = 12.7 h; beta(+), 17.4%; beta(-), 39%) has been used both in positron emission tomography imaging and in radiotherapy. Copper-64 radiopharmaceuticals have shown tumor growth inhibition with a relatively low radiation dose in animal models; however, the mechanism of cytotoxicity has not been fully elucidated. These studies incorporate the use of somatostatin receptor-positive ...

Background: Copper-64 (T1/2=12.7 h) is an important radionuclide used both in PET imaging and therapy. [64Cu]-pyruvaldehyde-bis (N4-methylthiosemicarbazone) ([64Cu]-PTSM) is one of the most famous copper radiopharmaceuticals with unique specifications (suitable half life, stability, etc.). The wide range of 64Cu applications arouse great interest for its production. Materials and Methods: Cu-64...