Copper resistance in Pseudomonas syringae carrying the copABCD operon is associated with accumulation of copper in the periplasm and outer membrane, apparently as a function of the copper-binding activities of the copABC gene products. However, no specific function for copD has been determined. In this study, P. syringae cells containing copCD or copBCD cloned behind the lac promoter were hyper...

An abnormal copper metabolism can cause hepatic copper accumulation and subsequently an increase in oxidative stress. We therefore analyzed the copper metabolism pathways and (non)enzymatic defenses against ROS in three different forms of chronic liver failure in the dog. Chronic hepatitis caused by inherited copper toxicosis (Copper toxicosis, CT) was compared to chronic hepatitis of unknown e...

Wilson’s disease (WD) is an inherited autosomal recessive disorder that lead to copper accumulation in the liver, brain, cornea, and other organs [1]. WD is treatable by life-long decoppering therapy with the aim of removing excess copper and preventing re-accumulation. This is accomplished with two main groups of drugs: chelating agents, including d-penicillamine (DPA) and trientine, that prom...

Copper-resistant strains of Pseudomonas syringae carrying the cop operon produce periplasmic copper-binding proteins, and this sequestration outside the cytoplasm has been proposed as a resistance mechanism. In this study, strain PS61 of P. syringae carrying the cloned cop operon accumulated more total cellular copper than without the operon. Several other copper-resistant pseudomonads with hom...

OBJECTIVE Dietary fructose and copper interaction may play an important role in the pathogenesis of nonalcoholic fatty liver disease. In this study, whether or not modest fructose consumption (3% fructose, w/v) (which is more closely related to the American lifestyle with regard to sugar beverage consumption) affects copper status, and causes liver injury and fat accumulation in marginal copper...

Chronic copper poisoning was investigated in ruminants within the Phalaborwa area of the Kruger National Park (KNP). Exposure of ruminants to environmental copper pollution resulting form copper smelting operations of a mine in the area was examined by comparing impala faecal copper concentrations in dung heaps and tissue (liver, lung and kidney) copper concentrations of organs collected from i...

Copper tolerance in Chlorella vulgaris has been studied by comparing physiological properties and copper uptake in a wild type strain and a copper tolerant one. A concentration dependent reduction in growth rate, dry mass, and content of chlorophyll a, protein, sugars and amino acids was noticed in both strains at 1.0 and 400 !g l 1 copper. The reduction in all parameters was higher in the wild...