Background: Physicians and geneticists face challenges in making accurate diagnoses during clinical evaluations; affecting patients clinicians. The aim of this study was to estimate the hit rate non-consanguineous population. Moreover, prevalence genetic disorder both consanguineous non- population Saudi Arabia at King Abdulaziz Medical City Riyadh data. Methods: We reviewed 681 families 1563 i...

Consanguinity or inter-cousin marriage is a phenomenon quite prevalent in certain regions around the globe. Consanguineous parents have a higher risk of having offspring with congenital disorders. It is difficult to model large scale consanguineous parental populations because of disparate cultural issues unique to regions and cultures across the globe. Although consanguinity has previously bee...

BACKGROUND The existence of a genetic component to human infertility has been suggested, although neither the specific abnormalities involved, nor their genetic mechanism of transmission, are currently defined. We have examined, by transmission electron microscopy (TEM), ejaculate from 1600 males with fertility problems. Among the subjects studied, we focused on a group of patients whose family...

A high occurrence rate of consanguineous marriages may favour the onset and increased frequency of autosomal recessive diseases in a population. The population of Monte Santo, Bahia, Brazil, has a high frequency of rare genetic diseases such as mucopolysaccharidosis type VI, whose observed frequency in this population is 1:5000, while the incidence of this disease recorded in other regions of t...

Consanguineous couples are at increased risk of having a child with a hereditary/congenital disorder. This extra risk is caused by the fact that the child can inherit the same mutated allele from both parents that originates from a common ancestor. First cousin couples are said to have 1.7-2.8% extra risk on top of the background risk that every couple has of having a child with a congenital/he...

The present study focuses on the effect of parental consanguinity on genetic disorders in the Iranian population, which is predominantly Muslim and where consanguineous marriages are quite common. Data were collected from three genetic centers from different areas of Tehran. Out of 800 affected subjects nearly 44% were born to consanguineous parents. While 37.8% of them were born out of paralle...

OBJECTIVES Consanguinity is a wide spread practice in Jordan. The objective of this study is to explore the health effects of consanguinity, in particular fertility, reproductive wastage, infant mortality and congenital malformations. METHODS A stratified 2 stage cluster sample of 1867 married couples, representative of all population groups and all geographic locations of Jordan were randoml...