CONTEXT There has been rapid adoption of newer radiation treatments such as intensity-modulated radiation therapy (IMRT) and proton therapy despite greater cost and limited demonstrated benefit compared with previous technologies. OBJECTIVE To determine the comparative morbidity and disease control of IMRT, proton therapy, and conformal radiation therapy for primary prostate cancer treatment....

Neoadjuvant radiation therapy, followed by definitive surgical resection, remains the standard of care for resectable high-grade and unresectable soft tissue sarcomas. Proton therapy offers the promise of highly conformal dose distributions with improved sparing of neighboring normal tissues as compared with conformal and intensity modulated photon techniques. It is unclear whether proton thera...

PURPOSE To assess the quality of cone beam computed tomography images obtained by a robotic arm-based and image-guided small animal conformal radiation therapy device. METHOD AND MATERIALS The small animal conformal radiation therapy device is equipped with a 40 to 225 kV X-ray tube mounted on a custom made gantry, a 1024 × 1024 pixels flat panel detector (200 μm resolution), a programmable 6...

The aim of conformal radiation therapy and of radiosurgery (Gamma Knife and Multi-beam radiosurgery) is to irradiate the pathological target volume with ionising radiation while avoiding as well as possible the surrounding normal tissues. Considering the accuracy of these treatments, it is interesting to compare the different techniques to evaluate their effectiveness. This comparison involves ...

Radiation therapy (RT) for prostate cancer has made huge strides over the past two decades. The addition of image guidance has allowed radiation oncologists to ensure accurate delivery of increasingly precise radiation treatment plans using newer conformal therapy methods such as three-dimensional conformal RT, intensity-modulated RT, and proton beam RT. Regardless of the specific treatment tec...

BACKGROUND We investigated how varying the treatment margin and applying hippocampal sparing and proton therapy impact the risk of neurocognitive impairment in pediatric medulloblastoma patients compared with current standard 3D conformal radiotherapy. METHODS We included 17 pediatric medulloblastoma patients to represent the variability in tumor location relative to the hippocampal region. T...

the mathematical aspect of cartographic mapping is a process which establishes a unique connection between points of the earth’s sphere and their images on a plane. it was proven in differential geometry that an isometric mapping of a sphere onto a plane with all corresponding distances on both surfaces remaining identical can never be achieved since the two surfaces do not possess the same gau...