INTRODUCTION The placenta contains efflux transporters, including P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP), that limit the passage of xenobiotics, certain hormones and nutrients from the maternal to the fetal circulation. The expression of these transporters changes with gestational age, yet the mechanisms involved remain unknown. However, the changes in P-gp and BCRP t...

In the past years, the development of oral formulations of the taxane anticancer drugs paclitaxel (Taxol ®) and docetaxel (Taxotere ®) has been the focus of preclinical and clinical research in our groups. A major limitation in the concept of oral administration of paclitaxel and docetaxel is their low oral availability [1]. Paclitaxel and docetaxel have poor aqueous solubility and upon oral ad...

The delivery method of [continuous (CONT) vs. every other day or intermittent (INT)] a glucogenic precursor (GP) which was contained glycerin (500 g/kg), mono-propylene glycol (250 g/kg), calcium propionate (150 g/kg), niacin (1 g/kg) and sulfate-Co (350 mg/kg) on performance, selected blood metabolites and liver enzymes were evaluated. Twenty-four multiparous Holstein fresh cows were ...

Let f(D(i,j),di,dj) be a real function symmetric in i and j with the property that f(d,(1+o(1))np,(1+o(1))np)=(1+o(1))f(d,np,np) for d=1,2. G graph, di denote degree of vertex D(i,j) distance between vertices G. In this paper, we define f-weighted Laplacian matrix random graphs Erdös-Rényi graph model Gn,p, where p?(0,1) is fixed. Four weighted type energies: energy LEf(G), signless LEf+(G), in...

To investigate the role of serotonin (5-HT), an important neurotransmitter and hormone/paracrine agent in the small intestine, in the transport activity of P-glycoprotein (P-gp), the intestinal transport of quinidine, a P-gp substrate, was examined in 5-HT-depleted rats prepared by intraperitoneal administration of p-chlorophenylalanine, a specific inhibitor of tryptophan hydroxylase in 5-HT bi...

In this paper we introduce condition (E?P) a generalization of Conditions (E?), (E) and (P) of acts over monoids and will give a classification of monoids by comparing this condition of their (Rees factor) acts with other properties. We give also a criterion of cyclic acts to satisfy Condition (E?P).

in this paper we introduce condition (e?p) a generalization of conditions (e?), (e) and (p) of acts over monoids and will give a classification of monoids by comparing this condition of their (rees factor) acts with other properties. we give also a criterion of cyclic acts to satisfy condition (e?p).