ignoring two main characteristics of the concentration-response data, correlation between observations and presence of outliers, may lead to misleading results. therefore the special method should be considered. in this paper in to examine the effect of phenylephrine in rat corpus cavernosum, outlier robust nonlinear mixed estimation is used. in this study, eight different doses of phenylephrin...

The 24-h area under the curve concentration (AUC24 h) is associated with better clinical and bacteriological response to vancomycin in patients methicillin-resistant Staphylococcus aureus who achieve target AUC24 h between 400 700 mg×h/L. Recent consensus recommends maintaining trough concentrations 15 20 mg/mL as a convenient target  reach an AUC/minimum inhibitory (MIC) ≥ 400. a...

OBJECTIVE To determine a concentration-effect curve of adalimumab in rheumatoid arthritis (RA) patients taking into account the effect of methotrexate (MTX) on concentration and effect and to identify a therapeutic range for adalimumab concentrations. METHODS In a prospective observational cohort study, 221 consecutive patients with RA were treated with 40 mg adalimumab subcutaneously every o...

National treatment guidelines for invasive methicillin-resistant Staphylococcus aureus (MRSA) infections recommend targeting a vancomycin 24-h area under the concentration-time curve (AUC0-24)-to-MIC ratio of >400. The range of vancomycin trough concentrations that best predicts an AUC0-24 of >400 in neonates is not known. This understanding would help clarify target trough concentrations in ne...