Objective(s): Multifunctional nanomedicine is the new generation of medicine, which is remarkably promising and associated with the minimum toxicity of targeted therapy. Distribution and transport of nanoparticles (NPs) in the blood flow are essential to the evaluation of delivery efficacy. Materials and Methods: In the present study, we initially designed a phantom based on Murray’s mini...

We have employed finite element analysis to develop computational Seebeck coefficient metrology simulations. This approach enables a unique exploration of multiple probe arrangements and measurement techniques within the same temporal domain. To demonstrate the usefulness of this approach, we have performed these Seebeck coefficient measurement simulations to quantitatively explore perturbation...

A method for the generation of quasi-isometric boundary-tted curvi-linear coordinates for arbitrary domains is developed on the basis of the quasi-isometric mappings theory and conformal representation of spherical and hyperbolic geometries. A one-parameter family of Riemannian metrics with some attractive invariant properties is analytically described. We construct the quasi-isometric mapping ...

This paper explores the role that social evaluation has in the definition of design as a source of innovation. The question of interest is how differences between the evaluative processes of group members can potentially determine the success or the failure of novel ideas in design. Computational simulations are presented of a simple design task in a social system where the effects of different...

A standard approach to solving inversion problems that involve many parameters uses gradient-based optimization to find the parameters that best match the data. We will discuss enabling techniques that facilitate application of this approach to large-scale computational simulations, which are the only way to investigate many complex physical phenomena. Such simulations may not seem to lend them...

in the present research, implementations of different computational geometry technologies in isogeometric analysis framework for computational fracture mechanics are investigated. nurbs and t-splines are two different computational geometry technologies which are studied in this work. among features of b-spline basis functions the possibility of enhancing a b-spline basis with discontinuities b...

It is necessary to obtain a fundamental understanding of the goaf gas flow patterns in longwall mine in order to develop optimum goaf gas drainage and spontaneous combustion (sponcom) management strategies. The best ventilation layout for a longwall underground mine should assist in goaf gas drainage and further reduce the risk of sponcom in the goaf. Further, in the longwall panel, regulators ...

In recent years, constant applied potential molecular dynamics has allowed to study the structure and of electrochemical double-layer a large variety nanoscale capacitors. Nevertheless it remained impossible simulate polarized electrodes at fixed total charge. Here we show that combining electrode with finite electric displacement fills this gap by allowing open circuit conditions. The method c...