Background Common Variable Immunodeficiency (CVID) is a Primary Immunodeficiency characterized by an association of IgG deficiency with IgA and/or IgM deficiency, and a decrease in the function of specific antibodies, discarding other causes of hipogamaglobulinemia. The recurrent pneumonia are among the main clinical manifestations of CVID,which appear between 20 and 40 years of age in most cas...

we have analysed data from 150 patients initially classified as having cvid. about 10% had laboratory abnormalities suggesting known single gene disorders (eg: hyper-igm syndrome), and in a few a genetic defect has been confirmed. we have attempted to sub-classify the remaining patients by analysis of their circulating lymphocytes. b lymphocyte markers have been used to estimate the numbers of ...

Common variable immunodeficiency (CVID) is the commonest primary immunodeficiency disease, which is characterized by frequent bacterial infections and hypogammaglobulinaemia. The prevalence of CVID is estimated at 1:25,000 in the Western world. Men and women are affected equally with a peak onset between 20 and 40 years. There is an average of 4–6 years between onset of symptoms and diagnosis. ...

Selective IgA deficiency (IgAD) is the most common primary immunodeficiency in Caucasians. Although it is often asymptomatic, selected patients show an increased frequency of infections, allergies and autoimmune manifestations. Common variable immunodeficiency (CVID) is a primary antibody deficiency disease that shares many clinical features with IgAD. A common genetic basis for IgAD and CVID h...

Background Common variable immunodeficiency (CVID) is one of the most common primary immunodeficiency in adults and is characterized by defective antibody production, low levels of serum immunoglobulins and increased susceptibility to infection. About 20% of developed different gastrointestinal pathology. But also the pathology of the gastrointestinal tract in patients with CVID showed a wide s...

common variable immunodeficiency (cvid) is one of the primary immunodeficiencies, which usually presents with recurrent bacterial infections, particularly in respiratory and gastrointestinal systems and hypogammaglobulinemia. we present here a case of cvid who was suffering from chronic watery diarrhea since 3 months before admission. past medical history was uneventful about recurrent infectio...

Common variable immunodeficiency (CVID) and selective IgA deficiency (SIgAD) are the most common primary immunodeficiencies in human. Both diseases share clinical manifestation and molecular defects. Increased apoptosis may be one of the mechanisms involved in the pathogenesis of CVID and SIgAD. Elevated apoptosis in this disorder leads to defective long-term survival of B-cells, reduced antibo...

Common variable immunodeficiency (CVID) is an immunodeficiency disorder with a high incidence of gastrointestinal (GI) manifestations and an increased risk of gastric malignancy. We report a case of a CVID with mild anemia presenting with multiple GI manifestations: gastric low-grade dysplasia (LGD), enteropathy with villous atrophy, refractory Giardia infection, nodular lymphoid hyperplasia, a...