colorectal cancer (crc) is the second leading cause of cancer death. progress has been made in the development of chemotherapy for advanced crc. targeted therapies against vegf or egfr are now commonly used. however, many cases show that tolerance develops to such treatments; therefore, new strategies are required to replace or complement current therapies. nuclear factor-?b (nf-?b) transcripti...

background colorectal cancer (crc) is one of the most common cancers worldwide which is not extensively researched in iran. objectives the present study aims to investigate the epidemiologic characteristics of crc in patients referred to selected hospitals of tehran university of medical sciences. patients and methods in this descriptive-analytic study 218 patients with colorectal cancer were i...

synchronous cancer is referred to two or more histological distinct malignancies diagnosed during the same hospital admission. globally more than 1 million people get colorectal cancer yearly resulting in about 0.5 million deaths. vulvar cancer is the fourth most common gynecologic cancer (following the corpus uterine cancer, cancer of ovary and cervix) and comprises only 4 percent of malignanc...

background: metastasis and recurrence of colorectal cancer after treatment is attributed to stem cells. the aim of this study was to determine the relationship between the expression of stem cell marker cd166 in colorectal cancer by immunohistochemistry and clinicopathologic parameters.methods: from 2006 to 2012, 121 colectomy specimens of patients with colon cancer that were operated in babol ...

background: clinical and epidemiological variation was seen between the colon cancer (cc) and rectum cancer (rc). so, there is not so much data available about the epidemiological and clinicopathological differences and prognostic factors regarding to cc and cr in iran, we aimed to perform this study. methods: all cases of cc and rc referred to oncology and gastroenterology wards of taleghani g...

aim :  to evaluate the association of dnmt1 and mgmt amino acid substitution polymorphisms and colorectal cancer in iranian population. background : the mgmt and dnmt1 are two important methyltransferase enzymes. amino acid substitution polymorphisms in mgmt and dnmt1 genes may be associated with the genetic susceptibility to sporadic colorectal cancer. patients and methods : we assessed eight ...

    Background: Colorectal cancer is one of the most common cancers in Iran. However little is known about the economic burden associated with this cancer in Iran. The aim of this study was to estimate the economic burden of colorectal cancer in Iran in the year 2012.    Methods: We used the prevalence-based approach and estimated direct and indirect costs of all color...