Results A 7 year-old girl was admitted to out patient clinic with a swollen and painful toe associated with lethargy and poor appetite; there was no rash, serositis, or eye inflammation, no muscle pain or weakness. Her history revealed that she had been followed up with a diagnosis of glycogen storage disease type 1 and neutropenia since she was 1 year-old. She had recurrent attacks of pain and...

The well-characterized anti-tubulin agent, podophyllotoxin (PTOX), with the 4'-position methoxyl group, targets the colchicines domain located between α- and β-tubulin. Two guanosine triphosphate (GTP) analogs of the tubulin-binding region were synthesized from PTOX, where a hydroxyl group was substituted with a carbon-sulfur bond. These compounds, 4-MP-PTOX and 4-TG-PTOX, reduce the dosage and...

Colchicine is used mainly for the treatment of gout and familial mediterranean fever. The use of colchicine is limited by its toxicity, and colchicine overdose is associated with a high mortality rate. Herein, we are reporting a young man who presented to the emergency department after ingesting 13.5 mg of colchicine and 1200 mg of aceclofenac (non-steroid anti-inflammatory drug) for deliberate...

BACKGROUND Gout is a metabolic disease that can manifest as acute or chronic arthritis, and deposition of urate crystals in connective tissue and kidneys. It can either manifest as acute arthritis or chronic tophaceous gout. CASE PRESENTATION We present a 39-year-old male patient who developed acute arthritis during his hospital course. Later on, after a careful physical examination, patient ...

PReS-FINAL-2204: Developing of a new scale for assessing the adherence to colchicines treatment in pediatric patients with FMF S Yesilkaya, C Acıkel, B Eren Fidanci, B Sozeri, N Aktay Ayaz, N Akıncı, G Ozcelik, S Kavukcu, Ü Aydogan, S Ozenc, S Emre, O Donmez, S Yuksel, A Delibas, A Berdelli, H Poyrazoglu, M Saldir, N Cakar, H Peru, S Bakkaloglu, Y Tabel, O Sari, A Polat, G Basbozkurt, E Unsal, ...

The methanolic, aqueous and petroleum ether extracts of the root tubers of Gloriosa superba were studied for antibacterial, antifungal and mutagenic activities. Results showed that the petroleum ether extracts were highly active against the Gram-negative bacteria, Escherichia coli, Proteus vulgaris and Salmonella typhi at 50 μg/ml and active at 1000 μg/ml against Gram-positive bacteria. All ext...

Methods Included were all patients, experiencing ≥1 attack per month, or intolerant to adequate dose of oral colchicin, for which they receive IV colchicine (pharmacy preparation under government control) for at least 1 year. Retrieval of data was based on patient interviews, files and a detailed questionnaire, focusing on clinical, demographic and genetic data. Effect of colchicine was determi...

We have shown previously that the beta-adrenergic agonist isoproterenol (2muM) and the phosphodiesterase inhibitor isobutylmethylxanthine (1 mM) produce a much greater increase in cyclic AMP in human leukocytes that have been pretreated with colchicine (or with other agents that affect microtubule assembly) than in control leukocytes. The effects of colchicines were both time- and dose-dependan...