Treatment of mitochondrial respiratory chain (MRC) disorders is extremely difficult, however, coenzyme Q10 (CoQ10) and its synthetic analogues are the only agents which have shown some therapeutic benefit to patients. CoQ10 serves as an electron carrier in the MRC as well as functioning as a potent lipid soluble antioxidant. CoQ10 supplementation is fundamental to the treatment of patients with...

This review discusses the role of coenzyme Q10 (CoQ10) in cardiovascular disease, hypertension, diabetes mellitus, and infertility. Deficiencies of CoQ10 have been documented in patients with heart disease. Administration of CoQ10 has been shown to prolong survival and improve quality of life in patients with cardiomyopathy. In patients with congestive heart failure, CoQ10 ameliorated symptoms,...

conclusions the results of the present study indicate that coenzyme q10 diminished neuronal necrosis and improved learning memory. part of its beneficial effect is due to its potential to discount oxidative stress. results this study revealed that the body weight scale was found to be significantly higher in the coq10 group (21.39 ± 2.70), compared to the tmt group (19.39 ± 2.74) (p < 0.05). in...

Riboflavin, which improves energy metabolism similarly to coenzyme Q10 (CoQ10), is effective in migraine prophylaxis. We compared CoQ10 (3 x 100 mg/day) and placebo in 42 migraine patients in a double-blind, randomized, placebo-controlled trial. CoQ10 was superior to placebo for attack-frequency, headache-days and days-with-nausea in the third treatment month and well tolerated; 50%-responder-r...

Coenzyme Q10 (CoQ10) is critical for the cell power supply in mitochondria. CoQ10 shuttles electrons from complexes I and II to complex III, and can be anti-oxdiative. Neurons require high energy for synaptic transmission and therefore the mitochondria dysfunction often leads to severe neuronal degeneration, as observed in many neurological disorders. CoQ10 supplementation has been widely used ...

Coenzyme Q10 (CoQ10) has a number of important roles in the cell that are required for optimal functioning immune system. These include its essential role as an electron carrier mitochondrial respiratory chain, enabling process oxidative phosphorylation to occur with concomitant production ATP, together potential lipid-soluble antioxidant, protecting against free radical-induced oxidation. Furt...

Coenzyme Q10(CoQ10) in human milk at different stages of maturity in mothers of preterm and full-term infants and its relation to the total antioxidant capacity of milk is described for the first time. Thirty healthy breastfeeding women provided colostrum, transition-milk and mature-milk samples. Coenzyme Q, alpha-, gamma- and delta-tocopherol, fatty acids and the total antioxidant capacity of ...

Primary coenzyme Q10 (CoQ10) deficiency is a rare mitochondrial disorder associated with 5 major clinical phenotypes: (1) encephalomyopathy, (2) severe infantile multisystemic disease, (3) cerebellar ataxia, (4) isolated myopathy, and (5) steroid-resistant nephrotic syndrome. Growth retardation, deafness and hearing loss have also been described in CoQ10-deficient patients. This heterogeneity i...

Coenzyme Q10 (CoQ10) is a lipid-soluble component from benzoquinones. The oxidized form of ubiquinone, and the reduced ubiquinol. As well to its endogenous synthesis, also included in diet. Dietary sources CoQ10 are meat, poultry, fish, oil, nuts. has an important role energy metabolism mitochondria. It protects phospholipids, proteins, DNA oxidative damage membrane. stated that several positiv...

Mitochondrial dysfunction and oxidative stress are the major events that lead to the formation of mitochondrial permeability transition pore (mPTP) during glutamate-induced cytotoxicity and cell death. Coenzyme Q10 (CoQ10) has widely been used for the treatment of mitochondrial disorders and neurodegenerative diseases. Comparing to traditional lipid-soluble CoQ10, water soluble CoQ10 (Ubisol-Q1...