Background: Most of the amino acids are encoded by more than one codon, termed as synonymous codons. Synonymous codon usage is not random as it is unique to species. In each amino acid family, some synonymous codons are preferred and this is referred to as synonymous codon usage bias (SCUB). Trends associated with evolution of SCUB and factors influencing its diversification in plastomes of gen...

background : colorectal cancer is the second cause of mortality in developed countries. the p53gene and some of it's polymorphisms are among the causes for cancer development.the purpose of this study is to evaluate the relationship between the p53 codon 72 polymorphism in colorectal adenocarcinoma specimens compared with controls. materials and methods : we performed a case-control study among...

background: little knowledge of synonymous codon usage pattern of pseudorabies virus (prv) genome, especially the ul31 gene in the process for its evolution is available. objectives: in the present study, the codon usage bias between prv ul31 sequence and the ul31-like sequences was identified. materials and methods: we used a comprehensive analysis on codon usage pattern in the prv ul31 gene a...

background: most of the amino acids are encoded by more than one codon, termed as synonymous codons. synonymous codon usage is not random as it is unique to species. in each amino acid family, some synonymous codons are preferred and this is referred to as synonymous codon usage bias (scub). trends associated with evolution of scub and factors influencing its diversification in plastomes of gen...

Background: In prostate cancer, mutated p53 alleles typically contain missense single-base substitution in codon 72 that resides within exons 5-8. Stable p53 proteins in tumor cell nuclei have been associated with malignancy. A role of p53 is the regulation of drug transporters like ABCC1 (MRP1) by an effect on promoter region. Objectives: The objective of this study was to identify association...

infectious bursal disease virus (ibdv) is the causative agent of gumboro disease, an infectious disease of global economic importance in poultry. structural protein vp2 of ibdv is the most frequently studied protein due to its significant roles in virus attachment, protective immunity, and serotype specificity. the objective of the present study was to improve the expression of hypervariable re...

conclusions: premature stop codon in the s gene was observed in all countries with evaluable hbv genome sequences. co-existence of detectable hepatitis b surface antigen (hbsag) and s gene premature stop codon was inconsistent with other studies. investigations on yield truncated hbsag are suggested to determine if they can affect elisa hbsag results. background: we have previously reported on ...

abstract objective: detection of p53 gene mutation on its codon 248 between iranian women with breast cancer by pcr-rflp. material and methods: dna extraction of tumor tissues was performed in 53 patients with primary breast cancer. designing primer for the sub-studying codon was performed with nti-vector software and detection of codon 248 mutation was done by msp i pcr_rflp. results: the soma...

Objective(s) P53 is an important tumor suppressor, which is mutated in later stages of many cancers and leads to resistance to chemotherapy. The aim of this study was to reveal mutations of TP53 in colorectal cancer in Kerman province. Materials and Methods A total of Forty-three colon cancer specimens as paraffin block or fresh tissues, which passed stage IIIA, were selected. Three exons 5,...