نتایج جستجو برای: coagulation inhibitors

تعداد نتایج: 234093  

Journal: :The journal of the Royal College of Physicians of Edinburgh 2014
H G Watson

For the first time in 50 years new oral anticoagulants of proven efficacy and with acceptable safety profiles are available for patients with atrial fibrillation and venous thromboembolism. Here is a brief overview of the benefits and possible disadvantages of using these drugs.

Journal: :British journal of haematology 2004
Nigel S Key

The development of inhibitory 'allo' antibodies to a deficient coagulation factor is arguably now the most severe and important complication of clotting factor concentrate exposure in haemophilia and other congenital coagulation disorders. Furthermore, development of an inhibitor to the factor VIII or factor IX transgene product remains a significant concern in gene therapy protocols for haemop...

2012
Imen Kraiem Samira Hadhri Halima El Omri Raja Sassi Wiem Chaabani Souad Ennabli Hadef Skouri

R a Abstract. Production of factor VIII or factor IX inhibitors is a major complication limiting the efficiency of substitutive therapy in haemophiliacs. Moreover, viral infections, the second serious complication of replacement therapy, may be associated to the occurrence of antiphospholipid antibodies which paradoxically lead to thrombosis. We investigated the prevalence of coagulation inhibi...

2015
YIDAN LIU Binghe Wang Yidan Liu Zhen Huang Gangli Wang Minyong Li Weixuan Chen

Fibrinogen aggregation is the last step in blood coagulation. Inhibition of fibrinogen aggregation could lead to anticoagulation effects. However, there is no good method for the ready evaluation of fibrinogen coagulation. A commonly used path method is slow and requires an expensive instrument. In this project, we have developed a microplate reader and In evaluating inhibitors of fibrinogen co...

Journal: :Journal of Applied Hematology 2016

Journal: :Blood 1988
R B Stricker P K Lane J D Leffert G M Rodgers M A Shuman L Corash

Although antibody inhibitors directed against blood coagulation factors are well known, antibody inhibitors directed against thrombin are rare. We describe three postsurgical patients with prosthetic cardiac valves who developed serum autoantibodies reactive with human and bovine thrombin, as demonstrated by coagulation studies and immunoblotting. Despite marked prolongation of the thrombin tim...

Journal: :British Journal of Clinical Pharmacology 2011

Journal: :Chest 2005
Sacha Zeerleder C Erik Hack Walter A Wuillemin

Disseminated intravascular coagulation is a frequent complication of sepsis. Coagulation activation, inhibition of fibrinolysis, and consumption of coagulation inhibitors lead to a procoagulant state resulting in inadequate fibrin removal and fibrin deposition in the microvasculature. As a consequence, microvascular thrombosis contributes to promotion of organ dysfunction. Recently, three rando...

Snakebite affects around 3 or 4 million humans annually leading to more than 100,000 deaths. Coagulopathy is one of the significant causes of both morbidity and mortality in these patients. Accordingly, it is of utmost importance to diagnose and treat coagulation disorder due to bites; in addition, it is accompanied by various clinical aspects, such as pre-coagulation, fibrinogen coagulation ti...

Journal: :international journal of hematology-oncology and stem cell research 0
mehrdad payandeh medical biology research center, kermanshah university of medical sciences, kermanshah, iran mohammad erfan zare medical biology research center, kermanshah university of medical sciences, kermanshah, iran; studen atefeh nasir kansestani medical biology research center, kermanshah university of medical sciences, kermanshah, iran; studen kamran mansouri medical biology research center, kermanshah university of medical sciences, kermanshah, iran; departmant zohreh rahimi medical biology research center, kermanshah university of medical sciences, kermanshah, iran; departmant amir hossein hashemian department of biostatistics, faculty of public health, kermanshah university of medical sciences, kermanshah

introduction: normal homeostasis system has several inhibitor mechanisms in front of the amplifier’s natural clotting enzyme to prevent fibrin clots in the vessels. the main inhibitors of coagulation pathway are antithrombin (at), protein c and protein s. patients with hereditary deficiency of coagulation inhibitors are susceptible to venous thromboembolism (vte). one of the major clinical mani...

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