Momentum exchange devices such as reaction wheels and control moment gyroscopes (CMGs) form an important class of torque actuators for spacecraft attitude control. A single gimbal CMG comprises of a rapidly spinning rotor mounted on a gimbal. The orientation of the rotor can be changed by applying torque to the gimbal, and the reaction torque thus generated serves to control the spacecraft atti...

Signaling complexes are essential for the modulation of excitability within restricted neuronal compartments. Adaptor proteins are the scaffold around which signaling complexes are organized. Here, we demonstrate that the Camguk (CMG)/CASK adaptor protein functionally modulates Drosophila Ether-á-go-go (EAG) potassium channels. Coexpression of CMG with EAG in Xenopus oocytes results in a more t...

PURPOSE Existing data supports a relationship between pelvic floor dysfunction and lower urinary tract symptoms. We developed a survival model of pelvic floor dysfunction in the rabbit and evaluated cystometric (CMG), electromyographic (EMG) and ambulatory voiding behavior. MATERIALS AND METHODS Twelve female adult virgin rabbits were housed in metabolic cages to record voiding and defecation...

Eukaryotes require 3 DNA polymerases for normal replisome operations, DNA polymerases (Pol) α, delta and epsilon. Recent biochemical and structural studies support the asymmetric use of these polymerases on the leading and lagging strands. Pol epsilon interacts with the 11-subunit CMG helicase, forming a 15-protein leading strand complex that acts processively in leading strand synthesis in vit...

The eukaryotic replicative DNA helicase, CMG, unwinds DNA by an unknown mechanism. In some models, CMG encircles and translocates along one strand of DNA while excluding the other strand. In others, CMG encircles and translocates along duplex DNA. To distinguish between these models, replisomes were confronted with strand-specific DNA roadblocks in Xenopus egg extracts. An ssDNA translocase sho...

Original scientific paper Control Moment Gyroscope is one of the main sources of disturbance affecting the accuracy of attitude control system in the spacecraft. This paper concentrates on analysing and testing the micro-vibrations produced by CMG. To analyse its disturbance features systematically, the mechanical features of flywheel, frame and the entire CMG will be firstly studied, and then ...

CaMKII is critical for structural and functional plasticity. Here we show that Camguk (Cmg), the Drosophila homolog of CASK/Lin-2, associates in an ATP-regulated manner with CaMKII to catalyze formation of a pool of calcium-insensitive CaMKII. In the presence of Ca(2+)/CaM, CaMKII complexed to Cmg can autophosphorylate at T287 and become constitutively active. In the absence of Ca(2+)/CaM, ATP ...

Disassembly of the Cdc45-MCM-GINS (CMG) DNA helicase is the key regulated step during DNA replication termination in eukaryotes, involving ubiquitylation of the Mcm7 helicase subunit, leading to a disassembly process that requires the Cdc48 "segregase". Here, we employ a screen to identify partners of budding yeast Cdc48 that are important for disassembly of ubiquitylated CMG helicase at the en...

Adouble-gimbalcontrol-momentgyro (CMG) ismodeled usingLagrange’s equations,and an adaptive feedback control law is developed to follow a commandedCMG motion. The control law does not require knowledge of the mass properties of the CMG. A Lyapunovargument is used to prove that command following is achieved globally with asymptoticconvergence. Numerical simulationsare performed to illustrate the ...