Abstract Background Anticoagulation and antiplatelet therapy, mainstays for the prevention of thromboembolic disorders, are associated with an increased bleeding risk. Asundexian, a novel, potent reversible oral inhibitor factor XIa, is independent extrinsic coagulation pathway thus not expected to increase Purpose To determine absolute bioavailability (FAB), assess impact gastric pH modulators...

Let there be m parallel machines and n jobs, where a job j can be scheduled on machine i to take pi, j ∈ Z+ time units. The makespan Cmax is the completion time of a machine that finishes last. The goal is to produce a schedule with all n jobs that has minimum makespan. This is the makespan problem on unrelated parallel machines, denoted as R||Cmax. Assume p,q ∈ Z+ are constants, let A(p,q) = {...

AIM Circulating concentrations of endogenous compounds such as testosterone, complicate the analysis of pharmacokinetic parameters when these compounds are administered exogenously. This study examines the influence of three correction methods of accounting for endogenous concentrations on the determination of bioequivalence between two testosterone formulations. METHODS 12 healthy males rece...

During the summers (July and August) of 2002-2005, we measured interannual variation in maximum carboxylation rate (V(cmax)) within a Fagus crenata Blume crown in relation to climate variables such as air temperature, daytime vapor pressure deficit (VPD) and daily photosynthetic photon flux, leaf nitrogen per unit area (N(a)) and leaf mass per unit area (LMA). Climatic conditions in the summers...

We consider profit-maximization problems for combinatorial auctions with non-single minded valuation functions and limited supply. We obtain fairly general results that relate the approximability of the profit-maximization problem to that of the corresponding social-welfare-maximization (SWM) problem, which is the problem of finding an allocation (S1, . . . , Sn) satisfying the capacity constra...

We have previously introduced vertex attack tolerance (VAT) and unsmoothened VAT (UVAT), denoted respectively as τ(G) = minS⊂V |S| |V−S−Cmax(V−S)|+1 and τ̂(G) = minS⊂V |S| |V−S−Cmax(V−S)| , where Cmax(V − S) is the largest connected component in V − S, as appropriate mathematical measures of resilience in the face of targeted node attacks for arbitrary degree networks. Here we prove the hardness...

This report describes phase 1 clinical trials performed to assess interactions of oral isavuconazole at the clinically targeted dose (200 mg, administered as isavuconazonium sulfate 372 mg, 3 times a day for 2 days; 200 mg once daily [QD] thereafter) with single oral doses of the cytochrome P450 (CYP) substrates: bupropion hydrochloride (CYP2B6; 100 mg; n = 24), repaglinide (CYP2C8/CYP3A4; 0.5 ...

Great uncertainty exists in the global exchange of carbon between the atmosphere and the terrestrial biosphere. An important source of this uncertainty lies in the dependency of photosynthesis on the maximum rate of carboxylation (V cmax) and the maximum rate of electron transport (J max). Understanding and making accurate prediction of C fluxes thus requires accurate characterization of these ...

After a single oral dose of praziquantel with 250 ml of grapefruit juice, the area under the concentration-time curve and the maximum concentration in plasma of praziquantel (Cmax) were significantly increased (Cmax for water treatment, 637.71 +/- 128.5 ng/ml; and Cmax for grapefruit juice treatment, 1,037.65 +/- 305.7 ng/ml, P < 0.05). No statistically significant differences were found in the...

The objective of this report was to study the pharmacokinetics of rifampin (RMP), isoniazid (INH), and pyrazinamide (PZA) in HIV-infected children with tuberculosis (TB) treated with a thrice-weekly anti-TB regimen in the government program in India. Seventy-seven HIV-infected children with TB aged 1 to 15 years from six hospitals in India were recruited. During the intensive phase of TB treatm...