Background: Most preclinical studies are carried out on mice. For internal dose assessment of a mouse, specific absorbed fraction (SAF) values play an important role. In most studies, SAF values are estimated using older standard human organ compositions and values for limited source target pairs.Objective: SAF values for monoenergetic photons of energies 15, 50, 100, 500, 1000 and 4000 keV...

BACKGROUND Despite being the conventional choice, whole body PET cameras with a 76 cm diameter ring are not the optimal means of human brain imaging. OBJECTIVE In fact, a dedicated brain PET with a better geometrical structure has the potential to achieve a higher sensitivity, a higher signal-to-noise ratio, and a better imaging performance. METHODS In this study, a polyhedron geometrical d...

HET/SAF-B was originally cloned as a nuclear matrix protein that bound to matrix attachment regions and as a transcriptional repressor of the small heat shock protein hsp27. In addition, we have found recently that HET/SAF-B is also a corepressor of estrogen receptor activity. Estrogen receptor has a very well-described role in breast cancer, and aberrant expression of nuclear matrix and heat s...

Serum amyloid A-activating factor-1 (SAF-1) is a zinc finger transcription factor that is activated by many mediators of inflammation including IL-1, IL-6, and bacterial LPS. However, the mechanism of activation is not fully understood. To identify possible activation partners for SAF-1, we used a yeast two-hybrid system that detected interaction between the catalytic subunit of cyclic AMP-depe...

Accurate determination of the amount of incoming solar radiation at Earth’s surface is important for both climate studies and solar power applications. Satellite-based datasets of solar radiation offer wide spatial and temporal coverage, but careful validation of their quality is a necessary prerequisite for reliable utilization. Here we study the retrieval quality of one polar-orbiting satelli...

OBJECTIVE The diagnosis of Cushing's syndrome (CS) remains a challenge in clinical endocrinology. The aim of this study was to determine the reproducibility and diagnostic value of late-night salivary cortisol (SAF(23)) for CS and its utility along the follow-up of treated patients. In addition, using the same radioimmunoassay reactives, the cut-off values for saliva and serum cortisol, assesse...

In this paper, we derive a polyphase analysis to determine the optimum filters in a subband adaptive filter (SAF) system. The structure of this optimum solution deviates from the standard SAF approach and presents its best possible solution only as an approximation. Besides this new insight into SAF error sources, the discussed analysis allows to calculate the optimum subband responses and the ...