Unintentional poisoning is the most common challenge during childhood age. Among them organophosphate, commonly used insecticide agent related to in children. Organophosphate causes up 25% of mortality worldwide. The present article discusses case a 3 year old child with accidental intake organophosphate revealing symptoms experienced by patient and different treatment modalities employed its o...

Background: The role and proper dose of pralidoxime in the treatment of Organophosphorus (OP) compounds poisoning is an unresolved issue .This study was designed to compare the regimen recommended by the World Health Organization (WHO) with the commonly used standard regimen of pralidoxime. Methods: This was a randomized open labeled prospective study on OP poisoned patients admitted to JSS Hos...

introduction: organophosphate compounds are used as insecticides, nerve gases, ophthalmic agents, and antihelmintics.the primary mechanism of action of organophosphate pesticides is inhibition of acetylcholinesterase (ache). however  pralidoxim has been introduced as organophosphate `s antidote but recent studies establish that pralidoxim has unclear benefit in treatment of organophosphate pois...

OBJECTIVES Poisoning by organophosphate insecticides causes cholinergic toxicity. Organophosphate induced delayed polyneuropathy (OPIDP) is a sensory-motor distal axonopathy which usually occurs after ingestion of large doses of certain organophosphate insecticides and has so far only been reported in patients with preceding cholinergic toxicity. Surprisingly, it was recently reported by other ...

organophosphate (op) poisoning is one of the most common causes of poisoning in developing countries especially in southeastern asia. poisoning with phosphorus-containing organic chemicals or op compounds can be managed with antidotes like oximes which are potential reactivators of acetylcholinesterase (ache). the efficacy of oxime therapy in op poisoned patients mainly depends upon various fac...

BACKGROUND Organophosphate poisoning is a major public health problem in South Africa. Individuals get exposed to organophosphate in both the domestic and industrial spheres. METHOD A cross-sectional study was conducted using retrospective, secondary data of organophosphate poisoning cases over a 3-year period, reported at the Tshwane District surveillance office. Data were analysed using Mic...

Dear Editor, Organophosphate insecticides have a triphasic effect on the central nervous system, namely acute cholinergic crisis, intermediate syndrome and delayed polyneuropathy. Although acute organophosphate poisoning is relatively common, case reports describing parkinsonism as a neurological complication following an acute intoxication are limited.1 We report a case of parkinsonism noted o...

INTRODUCTION Acute exposure to pesticide due to suicidal poisoning is the most extensive cause of pesticide exposure, compared with all other causes including agricultural or industrial exposure. Organophosphate (OP) and carbamate group of pesticides can inhibit acetylcholinesterase; on the other hand, paraoxonase1 can detoxify organophosphate poisoning by hydrolyzing organophosphate metabolite...