clinical trial committee (ctc) has been established in food and drug organization (fdo), in 2003 to assure efficacy and safety of all types of medicinal products which are meant to be registered in iran drug list and/or obtain market authorization.all clinical trial files, meeting minutes and databases in ctc secretariat in fdo were reviewed. relevant information and data extracted, analyzed an...

conclusions project management may benefit both the managerial and scientific aspects of medical projects and reduce fund waste. however, little has been written to date on project management in the context of clinical research. the suggestions represent the views of the individual authors. to provide a high level of evidence in this regard, we recommend that a randomized controlled trial be pe...

background: intrauterine insemination (iui) is one of the most appropriate and cost-effective methods in infertility treatment. objective: we aimed to investigate effect of vaginal misoprostol on pregnancy rate after iui. materials and methods: two hundred and ten infertile women who were referred to infertility clinic of alzahra hospital by an indication of iui during 2012-2013 were randomly a...

background: hepatorenal syndrome (hrs) is known as development of acute renal failure in a patient who usually has advanced liver disease. the aim of the present study was to determine the safety and the efficacy of noradrenalin in comparison with midodrine‑octreotide in patients with hrs. methods: this study was registered to the iranian registry of clinical trials (irct). this study was a sin...

background: poor sleep quality (sq) is common among patients after coronary artery bypass graft surgery (cabg). this study attempted to determine the status of sq following an intervention based on the precede-proceed model in patients with poor sq after cabg. methods: this study was a randomized clinical trial. the study sample, including 100 patients referred to the cardiac rehabilitation cli...

background: stem cell therapy is a new treatment option for different diseases. the aim of this systematic review is assessing the articles that focus on sct in iran and evaluate the amount of their success, failure and complication. methods: systematic search was conducted for finding english and persian papers (controlled trials and cohort studies with follow up) published before march 2015. ...

adverse effects of antituberculosis agents such as hepatotoxicity may reduce treatment effectiveness, because they significantly contribute to nonadherence and eventually result in treatment failure, relapse or the emergence of drug resistance. garlic is an ancient herbal substance, which its effectiveness on isoniazid and rifampicin-induced hepatic injury in animal models has been demonstrated...

background & aim : dietary behavior modification has an important effect on chronic disease occurrence. this study aimed to examine the effects of an education program on nutritional knowledge, attitude, and behavior among female students studying in bojnord, iran. methods & materials : this was a clinical trial that was conducted in 2009. of all secondary schools, 2 classes were randomly selec...

conclusions our findings did not support the use of zataria multiflora boiss in premenstrual syndrome. results thirty-eight students in intervention and 37 students in placebo group completed the study. the groups had no significant difference regarding the severity of pms. both groups showed a significant improvement in pms severity score after the intervention. the repeated-measure analysis o...

background and aims. standard treatment of oral lichen planus (olp) includes topical or systemic corticosteroids that have many adverse effects. a trend toward alternative natural or herbal drugs has attended recently. this study was conducted to evaluate the effect of quercetin in treatment of erosive-atrophic olp. materials and methods. thirty patients participated in this randomized clinical...