Amyotrophic lateral sclerosis (ALS) belongs to a group of disorders known as motor neuron diseases. Despite being one of the most devastating diseases known, there is little evidence for diagnosing and managing patients with ALS. Clinical neurophysiologic tests are essential, when no biological marker exists to aid early diagnosis, not only in relation to diagnosis, but also in the development ...

Repetitive stimulation in midline and intralaminar regions of the thalamus causes widespread changes in ongoing cortical activity. Contrasting effects may be obtained from the same loci by low and high frequency stimulation. Thus, stimulation at 6-12/see produces recruiting responses (Morison and Dempsey 1942), whereas high frequency stimulation at the same recruiting sites induces low voltage,...