Subcutaneous immunotherapy (SCIT) is a classic form of allergen-specific that used to treat birch pollen induced allergic asthma. To investigate the underlying molecular mechanisms SCIT, we aimed profile lung samples explore changes in differential proteome before and after SCIT mice with Fresh lungs were collected from three groups female BALB/c mice: 1) control mice, 2) pollen-induced 3) SCIT...

We investigated the bronchodilating effect of intravenous MgSO4 in acute severe bronchial asthma. Infusion of MgSO4 caused a significant improvement in FEV1 (0.94 +/- 0.39L to 1.3 +/- 0.44 L) and an improvement in clinical signs and symptoms in ten out of 12 administrations. The bronchodilating effect of MgSO4, however, was significantly less than that of subsequent albuterol inhalation (FEV1 i...

Although assessment of asthma control is important to guide treatment, it is difficult since the temporal pattern and risk of exacerbations are often unpredictable. In this Review, we summarise the classic methods to assess control with unidimensional and multidimensional approaches. Next, we show how ideas from the science of complexity can explain the seemingly unpredictable nature of bronchi...

This article is devoted to two different generalizations of projective Boolean algebras: openly generated Boolean algebras and tightly σ-filtered Boolean algebras. We show that for every uncountable regular cardinal κ there are 2 pairwise non-isomorphic openly generated Boolean algebras of size κ > א1 provided there is an almost free non-free abelian group of size κ. The openly generated Boolea...

Wheezing/asthma in children is a complex problem due to its heterogeneous condition, with different pathogenic mechanisms, variations in duration and in severity; that make it difficult to totally understand. This relation between wheezing in infants and later development of asthma will be the result of alterations in the immune system maturation and congenital or acquired modifications of the ...

Asthma is a disease of civilisation par excellence. Its increasing incidence is cause for concern and several teams working around the world are attempting to untangle the complexity of its causes. The University of Liège has made a small step towards this understanding by identifying a protease whose role may prove to be very interesting ... Asthma may be defined as a reversible obstruction of...