Background Nowadays, health systems are generally acknowledged to be complex social systems. Consequently, scholars, academics, practitioners, and policy-makers are exploring how to adopt a complexity perspective in health policy and system research. While leadership and complexity has been studied extensively outside health, the implications of complexity theories for the study of leader...

Neuroendocrine (NE) differentiation of prostate epithelial/basal cells is a hallmark of advanced, androgen-independent prostate cancer, for which there is no successful therapy. Here we report for the first time on alterations in regulatory volume decrease (RVD) and its key determinant, swelling-activated Cl- current (I(Cl,swell)), associated with NE differentiation of androgen-dependent LNCaP ...

Physiology is generally considered to consist of that branch of biology concerned with the function of liv­ ing organisms and the underlying physicochemical processes, with gen­ eral physiology specifically concerned with the analytical investigation of the molecular and cellular mecha­ nisms of fundamental physiologi­ cal processes. The Journal of General Physiology (the JGP) was founded by Ja...

by KARAN SHARMA (Under the Direction of Walter D. Potter) ABSTRACT In spite of the impressive successes of many Artificial Intelligence techniques in narrow domains, one of the unrealized goals of AI remains the creation of a generally intelligent machine. It is hypothesized that the capacity for being creative in a wide variety of environments is a necessary and sufficient condition for genera...

The reduced binding of pyrimethamine to Ser108Asn (S108N) mutants of parasite dihydrofolate reductase (DHFR), which forms the basis of resistance of Plasmodium falciparum to pyrimethamine, is largely due to steric constraint imposed by the bulky side chain of N108 on Cl of the 5-p-Cl-phenyl group. This and other S108 mutants with bulky side chains all showed reduced binding to pyrimethamine and...

Recent studies have demonstrated that participants with an abstract mind-set (high construal level [CL]) showed an increased risk affinity when compared with those with a concrete way of thinking (low CL). With regard to the importance of replicating research findings, we conducted a replication study and re-investigated the CL effect on risk-taking. Furthermore, we extended previous research b...