BACKGROUND/AIM Cytokeratin (CK) 20 expression is an independent prognostic factor of poorly differentiated adenocarcinoma (PDA) of the colon and rectum. We aimed to investigate the mechanism of its involvement through a clinicopathological study. PATIENTS AND METHODS We analyzed 156 surgically resected PDAs, which were sub-classified as solid type (Por1) showing expansive growth, or non-solid...

PURPOSE Unexpected reverse transcription-PCR detection of cytokeratin 20 (CK20) in samples from healthy individuals and cancer types not expected to express CK20 has cast uncertainty on the role of CK20 as a specific marker of disseminated colorectal cells. We aimed to clarify the specificity of CK20 by examining its expression profile by real-time reverse transcription-PCR. EXPERIMENTAL DESI...

Reactive urothelial atypia (RUA) can be difficult to differentiate from dysplastic urothelium. The goal was to evaluate the efficacy of cytokeratin 20 (CK20), Ki-67 and E-cadherin (E-Cad) in this regard. Fifty carcinoma in situ (CIS) cases, 50 non-neoplastic urothelia (25 normal, 25 reactive urothelial atypia (RUA)) and 17 atypia of unknown significance (AUS) cases were evaluated. All cases wer...

Background & Objective: The role of synchronized expression pattern of cytokeratin (CK) 7 and CK20 in the prognosis of colon adenocarcinoma is unclear. The current study aimed at determining the relationship between the expression of cytokeratins 7 and 20 and prognostic factors in colon adenocarcinoma. Methods: In the current cr...

BACKGROUND Because of the poor sensitivity of urinary cytological findings for the diagnosis of especially low grade urinary bladder carcinoma, new molecular diagnostic methods have been proposed. We decided to verify the ImmunoCyt/uCyt+ (UCyt+) test and cytology combination and cytokeratin 20 (CK20) and cytology combination in urine as possible diagnostic and monitoring tool for bladder cancer...

Aim: The histologic features, potential behavior, genetic pathways, epidemiological characteristics and response to treatment of gastric carcinomas, is showing heterogeneity. Cytokeratin (CK), an intermediate-sized filament detected primarily in epithelial cells. Most commonly used CKs in immunohistochemical studies are CK7, CK20 and these molecules are used as a markers to help identify the si...

Herein, correlations between expression levels of CK20 and efficacy of treatment and postoperative prognosis of colorectal cancer were evaluated to elucidate the clinical value of CK20. Postoperative follow-up was performed on 62 patients who underwent surgery for colorectal cancer between January 2010 and December 2010. Samples of tumor tissues and intraperitoneal drainage fluids were collecte...

Introduction: Cancer is malignant disease, one of the leading cause deadth at global level. The determination origin tumors really essential for not only prognosis but also effective treatment orientation cancerous patients. Objective: Defining histopathological types epithelial and determining by CK7, CK20 other immunohistochemical markers. Patients methods: A cross-sectional study 50 patients...

Background & Objective The role of synchronized expression pattern of cytokeratin (CK) 7 and CK20 in the prognosis of colon adenocarcinoma is unclear. The current study aimed at determining the relationship between the expression of cytokeratins 7 and 20 and prognostic factors in colon adenocarcinoma. Methods In the current cross sectional Study, 52 archival samples of colon adenocarcinoma wi...

AIM To investigate whether immunohistochemical staining for cytokeratin 20 (CK20) and thyroid transcription factor 1 (TTF-1) is useful in distinguishing Merkel cell carcinomas (MCCs) from metastatic small cell carcinomas (SCCs). METHODS Eleven cases of MCC and 10 of lung SCC were stained for CK20 and TTF-1. RESULTS Ten of 11 MCCs stained with the antibody to CK20. None was positive for TTF-...