Cisplatin is the first heavy metal compound that has been found to possess antineoplastic activity. It effective in treating testicular, ovarian, head and neck, bladder, cervical, esophageal tumors, small cell lung carcinoma. Approximately 1% of cisplatin enters interacts with DNA, forming DNA-cisplatin bonds. Both apoptosis necrosis can be same population cells exposed cisplatin, mode death de...

Objective(s) Portulaca oleracea L. is a herbaceous weed from portulacaceae family. It can be found in many parts of the world. Modern pharmacological studies have demonstrated that P. oleracea have antioxidant effects. The protective effect of aqueous and ethanolic extract of P. oleracea against cisplatin-induced renal toxicity was studied in rats. Materials and Methods Single intraperitonea...

objective(s):the purpose of the present study was to investigate the protective effect of oxytocin on cisplatin (cp)-induced renal damage in rats. materials and methods: fourteen adult sprague dawley rats, weighing 200 to 210, were administered by cisplatin (cp, 2 mg/kg/day) twice a week for five weeks. then, they were randomly divided into two groups and treated with either saline (1 ml/kg/day...

Cisplatin is an effective chemotherapeutic drug used to treat many types of tumours. However, it may cause male reproductive toxicity. Gallic acid exhibits beneficial effects such as antioxidant, anti-inflammatory and antitumor. The current study investigated the gallic against testis epididymis toxicity induced by cisplatin. Male rats were divided into 4 groups follows (n = 7): Control, cispla...

objective: the clinical use of cisplatin is highly restricted, because of its nephrotoxicity.in this study the protective effect of nigella sativa (n. sativa) against cisplatin-induced nephrotoxicity was investigated in rats. materials and methods: in the current study, the effects of the administration of aqueous-ethanolic extract of n. sativa (100 and 200 mg/kg, bw) and vitamin e (100 mg/kg, ...

*Corresponding author: Prof. Hamid Nasri, Department of Nephrology, Division of Nephropathology, Isfahan University of Medical Sciences, Isfahan, Iran. E-mail: [email protected] It is established that cisplatin therapy is accompanied by damage to the kidneys (1). However, cisplatin is an applicable antineoplastic agent, against solid tumors in clinic (1,2). Cisplatin or cis-diamminedichlorop...

AIMS To evaluate the adverse effect and survival outcome of weekly and triweekly cisplatin with radiotherapy in treatment of cervical cancer. METHODS After an extensive literature search between 1995-2011,we analyzed 7 studies to compare weekly cisplatin and triweekly cisplatin combined radiotherapy. RESULTS Our analysis established that weekly cisplatin has a lower risk of hematologic toxi...

background antioxidant effects of propofol (2, 6-diisopropylphenol) were evaluated against cisplatin-i‎nduced oxidative stress in rat. objectives in this experimental study, 20 male rats were equally divided into 4 groups (5 rats each), and were treated by propofol (10 mg/kg/day, ip), or cisplatin (7 mg /kg/day, ip), or both. conclusions it is concluded that oxidative ‎damage is the mechanism o...

Toll-like receptor 4 (TLR4) recognizes bacterial lipopolysaccharide (LPS) and can also be activated by some Group 9/10 transition metals, which is believed to mediate immune hypersensitivity reactions. In this work, we test whether TLR4 the 10 metal platinum platinum-based chemotherapeutic cisplatin. Cisplatin invaluable in childhood cancer treatment but its use limited due a permanent hearing ...

introduction: the principal dose-limiting factor in the use of cisplatin as an antineoplastic drug is its hepatic toxicity. this study was designed to investigate the protective role of taurine against cisplatin-induced hepatic injury. methods: male albino rats (180-220 g) were divided in to 4 groups (n=8) as follows: (1) saline-treated group (2): cisplatin-treated group (10 mg/kg ip) (3): grou...