Poor outcome of extramedullary disease in multiple myeloma patients and lack of outcome predictors prompt continued search for new markers of the disease. In this report, we show circulating microRNA distinguishing multiple myeloma patients with extramedullary disease from myeloma patients without such manifestation and from healthy donors. MicroRNA-130a was identified by TaqMan Low Density Arr...

Purpose: The main purpose of our study is to research the potential circulating microRNA-122 (miR-122)as a marker for hepatocellular carcinoma.
 Materials and Methods: Circulating miR-122 levels were measured by real-time polymerase chain reaction in patients with varied stages carcinoma. In addition, various other laboratory clinical data participants evaluated order observe correlation b...

Effective diagnosis and surveillance of complex multi-factorial disorders such as cancer can be improved by screening of easily accessible biomarkers. Highly stable cell free Circulating Nucleic Acids (CNA) present as both RNA and DNA species have been discovered in the blood and plasma of humans. Correlations between tumor-associated genomic/epigenetic/transcriptional changes and alterations i...

GOALS In this clinical study, we aimed to evaluate the role of circulating microRNA-200 family as a non-invasive tool to identify patients with cirrhosis-associated hepatocellular carcinoma (HCC). BACKGROUND Prognosis of HCC remains poor with increasing incidence worldwide, mainly related to liver cirrhosis. So far, no reliable molecular targets exist for early detection of HCC at surgically ...

There is an error in the third sentence of the Identification of small RNAs within bovine serum via RNA-seq section of the Results. The correct sentence is: On average, 54% mapped to tRNA, ~10% to other non-miRNA databases while 13% of reads could not be reliably mapped at all (Fig 3A). There are errors in Table 1. The publisher apologizes for these errors. Please see the corrected Table 1 here.

Circulating microRNAs in body fluids have been implicated as promising biomarkers for physiopathology disorders. Currently, the expression levels of circulating microRNAs are estimated by reverse transcription quantitative real-time polymerase chain reaction. Use of appropriate reference microRNAs for normalization is critical for accurate microRNA expression analysis. However, no study has sys...

Abstract Introduction Arterial hypertension (AH) is the most common cardiovascular (CV) diseases and one of major a risk factor for CV complications mortality. An important reason development progression number are epigenetic factors regulating gene expression, which include microRNAs. MicroRNA-133a epigenetics factor, has cardioprotective properties, but its role in left ventricular hypertroph...

BACKGROUND MicroRNA expression is altered in cancer cells, and microRNAs could serve as diagnostic/prognostic biomarker for cancer patients. Our study was designed to analyze circulating serum microRNAs in patients with renal cell carcinoma (RCC). METHODOLOGY/PRINCIPAL FINDINGS We first explored microrna expression profiles in tissue and serum using taqman low density arrays in each six malig...

OBJECTIVE To investigated the circulating microRNA expression profile in sepsis and its clinical evaluation. METHODS 70 patients with sepsis and 30 patients with SIRS were selected and their blood samples were collected. Using liquid bead array with 3 statistical analysis approaches analyzed the circulating microRNA expression profiles, for confirming the data of liquid bead array, qRT-PCR wa...