A methanolic extract of dried leaves of Polygala japonica Houtt (Polygalaceae) significantly attenuated nitric oxide production in lipopolysaccharide-simulated BV2 microglia. Five anthraquinones chrysophanol (1), emodin (2), aloe-emodin (3), emodin 8-O-beta-D-glucopyranoside (4) and trihydroxy anthraquinone (5), and four flavonoids kaempferol (6), chrysoeriol (7), kaempferol 3-gentiobioside (8)...

Two new phenylethanoid glycosides integrifoliosides A (2) and B (3), along with a known phenylethanoid glycoside alyssonoside (1) and a flavone glucoside chrysoeriol-7-O-beta-D-glucopyranoside (4) were isolated from the aerial parts of Phlomis integrifolia. The structures of the new compounds were identified as 3,4-dihydroxy-beta-phenylethoxy-O-beta-D-apiofuranosyl-(1 --> 4)-alpha-L-rhamnopyran...

Background and objectives: Phlomis bruguieri Desf. (Lamiaceae) is a perennial herbaceous plant distributed in Iran, Turkey and Iraq. Despite medicinal potentials of this species, the current knowledge on its phytochemical constituents is limited. The aim of the present study was to investigate the phytochemical constituents of the essential oil and various extracts of ...

salvia genus is one of the largest genera of the lamiaceae family. its species have been used for a wide variety of disorders in the local traditional medicine systems. therefore, the genus has been the subject of several phytochemical and biological studies. the aim of the study was to identify the major antioxidant compound(s) from the methanol extract of salvia verticillata using activity-gu...

In extracts of the seagrass Zostera marina, collected in coastal waters of West-Norway, fourteen different flavones and high amounts of rosmarinic acid were identified. Five of the flavones were found to be sulphated, among these were luteolin 7,3'-disulphate and chrysoeriol 7-sulphate structures previously not published with complete NMR assignments. Luteolin 7-O-β-(6''-malonyl) glucoside, and...

Phytochemical investigations of chloroform and ethyl acetate extracts from the aerial parts of Warionia saharae Benth. & Coss. from Algeria resulted in the isolation of ten known compounds: β-sitosterol, stigmasterol, scopoletin, cirsimaritin, chrysoeriol, hispidulin, luteolin, esculetin, (2R,3R) taxifolin, quercetin. Their structures were elucidated on the basis of extensive spectroscopic anal...

It is now believed that the inhibition of carbohydrate hydrolyzing enzymes (CHEs) in the digestive tract can significantly prolong the overall carbohydrate digestion time and decrease the postprandial hyperglycemia after a meal. Therefore, inhibitors of CHEs can be useful therapeutic approaches in the management of diabetes mellitus, especially in the type 2, and complications associated with t...

We studied the effects of twelve 5,7-dihydroxyflavone analogs on adipogenesis in 3T3-L1 cells. Among the compounds, luteolin, diosmetin, and chrysoeriol partly inhibited adipogenesis by blocking the accumulation of triacylglycerol in the cells. Conversely, tricetin facilitated triacylglycerol accumulation in the cells. The induction of lipogenesis or lipolysis may depend on the number and bondi...