Stress is a reaction to unwanted events disturbing body homeostasis which influences its pathways and target areas. Stress affects the brain through the lateral hypothalamic area (LHA) orexinergic system that mediates the effect of corticotropin-releasing hormone (CRH) through CRH receptor type 1 (CRHr1). Therefore, this study explores the outcome of stress exposure on anxiety development and t...

Background: Stress predisposes organisms to depression and cognitive impairments, and seems to interact with metabolic homeostasis. The inflammatory response and the upregulation of proinflammatory cytokines are some of the consequences related to chronic stress. In this study, we investigated the preventive effect of chronic administration of ibuprofen, as an inhibitor of cyclooxygenases, on t...

Abstract Introduction: Chronic heterogeneous stress may be better for evaluation of the effect of chronic stress situations on the nociceptive behaviour. The present study investigated the effects of chronic heterogeneous sequential stress on thermal-induced nociception and formalin induced pain behavior in rats. Methods: In the present study, adult rats (220-300 g) were used. Animals were ...

Introduction: Certain types of chronic mental stress impair memory. On the other hand, crocin is introduced in the medical literature as an effective component of saffron with remedial effects on memory impairment. This study investigated the effects of crocin on spatial and cognitive memories, locomotor activity, novel recognition conditions and serum corticosterone levels in rats under chroni...

background: parents of children with developmental problems are always bearing a load of stress. the aim of this study is to compare the stress in mothers of children with different disabilities to each other, considering their demographic background. materials and methods: this was a cross-sectional study conducted in isfahan, iran during 2012 on 285 mothers of 6-12 years old children with chr...

based on the evidence regarding the relationship between inflammatory processes and stress responses, the present study investigated the association between psychological stress and elevation of inflammatory mediators related to periodontal disease in adult patients.the study consisted of 50 patients including 25 patients with chronic periodontitis and 25 cases with aggressive periodontitis. tw...

this paper presents the effect of high environmental heat on behavior of the male charles foster rats. eighty rats were divided into three groups, subjected to (i) acute heat stress (ii) chronic heat stress and (iii) handling control group. animals were exposed to the hot environment in a biological oxygen demand incubator at 38 ± 1ºc (relative humidity 45-50%) for four hours of continuous sing...