abstractintroduction: diabetes mellitus is the most common human metabolic disease and chronic non healing diabetic foot ulcers are a critical complication for these patients. angipars is a new herbal extract which has been introduced to accelerate healing of these ulcers. the purpose of this study was to investigate the efficacy and safety of oral angipars in patients with chronic diabetic foo...

Vrana is a clinical condition which occupies the area of skin and remains till body survives. Dushta having features Durgandha (bad smell), Pooyayukta (pus filled), Utsangi (elevated), Chirakali (chronic), Dooshita (afflicted by Tridosha vitiation), Atigandha Varna Srava (discharge with excessive odour coloured), Vedanayukta (painful) opposite to Shuddha (healing wound). Diabetic foot ulcer glo...

The central portion of chronic wounds is often hypoxic and relatively hypothermic, representing a deficient energy supply of the tissue, which impedes wound healing or even makes it impossible. Water-filtered infrared-A (wIRA) is a special form of heat radiation with a high tissue penetration and a low thermal load to the skin surface. wIRA produces a therapeutically usable field of heat and in...

background: at present, surgery is the best method for chronic anal fissure, but by acquiring more knowledge about the pathogenesis and function of internal anal sphincter, non surgical treatment such as using of glycerin trinitrate, isosorbide, bethancol, diltiazem and butilinum toxin has been suggested. there is controversy about using of l-arginine. the aim of the present study was to compar...

Wound healing is a process that can be divided into three different phases (inflammatory, proliferative, and maturation). Each is characterized by certain events that require specific components. However, wound healing is not always a linear process; it can progress forward and backward through the phases depending on various intrinsic and extrinsic factors. If the wound-healing process is affe...

Wound fluid seems -at least theoreticallyeasily accessible and might open a new window to the local wound microenvironment that cannot be evaluated by the analysis of serum or plasma markers. Recently, this strategy has been supported by a first time wound fluid proteome analysis comparing acute and chronic wounds (Eming et al. 2010). Interestingly, there seem to be essential differences with r...

The sex hormones oestrogen and testosterone are important mediators of wound repair. Oestrogen enhances wound healing by reducing inflammation and enhancing matrix production. However, in post-menopausal women, when oestrogen levels are decreased, wound healing is impaired and susceptibility to chronic non-healing wounds increases. Surprisingly, although the speed of healing is impaired, an imp...

The development of molecular biology and other new biotechnologies helps us to recognize the wound healing and non-healing wound of skin in the past 30 years. This review mainly focuses on the molecular biology of many cytokines (including growth factors) and other molecular factors such as extracellular matrix (ECM) on wound healing. The molecular biology in cell movement such as epidermal cel...

Objective: The healing effects of two different dilutions (5 & 100%) of N-Chromosome Royal Jelly and ANGIPARS ointment were investigated and measured on experimental injuries in streptozotocin (STZ)-induced diabetic rats. This study investigated the healing effects of 2 different N Chromosome Royal Jelly dilutions on injuries of STZ-induced diabetic rats. Materials and Methods: For diabetes in...