BACKGROUND Tyrosine kinase inhibitors, such as imatinib, are not considered curative for chronic myeloid leukemia--regardless of the significant reduction of disease burden during treatment--since they do not affect the leukemic stem cells. However, the stochastic nature of hematopoiesis and recent clinical observations suggest that this view must be revisited. DESIGN AND METHODS We studied t...

Background: Leptin has been implicated in the differentiation and proliferation of hematopoietic cells. Leukemia inhibitory factor (LIF) may play an important role, along with Interleukin-6 (IL-6) and granulocyte colony stimulating factor (G- CSF), in the regulation of early hematopoietic stem cells. The aim of the study was to evaluate serum level of leptin, LIF, and IL-6 in myeloid leukemia p...

background: leptin has been implicated in the differentiation and proliferation of hematopoietic cells. leukemia inhibitory factor (lif) may play an important role, along with interleukin-6 (il-6) and granulocyte colony stimulating factor (g- csf), in the regulation of early hematopoietic stem cells. the aim of the study was to evaluate serum level of leptin, lif, and il-6 in myeloid leukemia p...

homogeneously staining regions (hsr) or double minute chromosomes (dmin) are autonomously replicating extra-chromosomal elements that are frequently associated with gene amplifi cation in a variety of cancers. the diagnosis of leukemia patients was based on characterization of the leukemic cells obtained from bone marrow cytogenetics. this study report two cases, one with acute myeloblastic leu...

chronic lymphocytic leukemia (cll) and chronic myeloid leukemia (cml) are the most common leukemias of the elderly (>43 year). however, the sequential occurrence of cml followed by cll in the same patient is extremely rare. in our report, a 52-year-old female was diagnosed with cll (type of bone marrow (bm) infiltration was nodular and interstitial) and was treated with chlorambucil. 64 months ...

BACKGROUND Incubation of chronic myeloid leukemia cells in hypoxia inhibits growth and selects BCR/Abl-independent cells with stem cell properties which are refractory to imatinib-mesylate. This study aimed to characterize the relationship of this refractoriness with glucose availability in the environment. DESIGN AND METHODS K562 or primary chronic myeloid leukemia cells were cultured at 0.1...

background : according to the literature, there are a number of chronic and acute myeloid leukemias with unique, complex chromosome translocations. this study aims to conduct a brief review of the incidence of complex chromosome translocations in myeloid leukemia and reports a case of myeloid leukemia with complex chromosome translocations. methods :we conducted a web-based search for all peer ...

Chronic myeloid leukemia (CML) is typified by robust marrow and extramedullary myeloid cell production. In the absence of therapy or sometimes despite it, CML has a propensity to progress from a relatively well tolerated chronic phase to an almost uniformly fatal blast crisis phase. The discovery of the Philadelphia chromosome followed by identification of its BCR-ABL fusion gene product and th...

myeloproliferative neoplasms (mpns) such as polycythemia vera, essential thrombocythemia, primary myelofibrosis and chronic myeloid leukemia have too similar and accurate way to differentiate their is study of genetic disorders in these patients. philadelphia chromosome is a sure way to definitively diagnose cml. recently, jak2v617f mutation introduced as a diagnostic marker for other myeloprol...

BACKGROUND Residual chronic myeloid leukemia disease following imatinib treatment has been attributed to the presence of quiescent leukemic stem cells intrinsically resistant to imatinib. Mesenchymal stromal cells in the bone marrow may favor the persistence and progression of leukemia by preserving the proliferation and self-renewal capacities of the malignant progenitor cells. DESIGN AND ME...