Chronic lymphocytic leukemia is a disease with up-regulated expression of the transmembrane tyrosine-protein kinase ROR1, a member of the Wnt/planar cell polarity pathway. In this study, we identified COBLL1 as a novel interaction partner of ROR1. COBLL1 shows clear bimodal expression with high levels in chronic lymphocytic leukemia patients with mutated IGHV and approximately 30% of chronic ly...

BACKGROUND Previous studies have shown increased familial risk for chronic lymphocytic leukemia. In the most comprehensive study to date, we evaluated risk of chronic lymphocytic leukemia and lymphoproliferative disorders among first-degree relatives of chronic lymphocytic leukemia cases compared to first-degree relatives of controls. DESIGN AND METHODS Population-based registry data from Swe...

Background: Leukemia is one of the major causes of mortality and disability and the seventh most prevalent cancer worldwide. It has various effects on different aspects of physical, psychological, reproductive, social, and economic performance of human life. This study compared the quality of life of patients with different types of leukemia hospitalized in Ayatollah Khansari Hospital in Arak- ...

Chronic lymphocytic leukemia, the most common adult leukemia worldwide, is considered an indolent but incurable non-Hodgkin lymphoma. Leukemia cutis is an uncommon manifestation of chronic lymphocytic leukemia. We present a case of an adult patient who presented with skin lesion of bilateral ears, which led to the diagnosis of chronic lymphocytic leukemia. We also reviewed the cases of auricula...

C HRONIC LYMPHOCYTIC LEUKEMIA is a rare disease in Japan. Since the Atomic Bomb Casualty Commission ( ABCC ) initiated its leukemia case-detection program in 1950 only a few patients with this disorder have been identified in the cities of Hiroshima and Nagasaki. In this report the incidence of chronic lymphocytic leukemia during a 20 year period in both Hiroshima and Nagasaki is compared with ...

By PETER McPHEDiw r AND CLARK W. HEATH, JR. T HE CONCEPT OF “BLAST CRISIS” in chronic leukemia implies a single disease process advancing from chronic to acute phase. How often this happens in chronic lymphocytic leukemia, or whether it happens at all, is uncertain. Unlike chronic granulocytic leukemia, chronic lymphocytic leukemia does not often end in acute leukemia. While it is possible that...

associations of some hematological and lymphatic diseases with sex and abo and rh blood groups were studied in 2579 patients, compared with a control group of 126332 individuals, by the use of clinical as well as laboratory findings, in tehran. highly significant increase of male/female ratio is shown in acute myelogenous leukemia, acute lymphocytic leukemia, chronic lymphocytic leukemia, aplas...

Concurrent development of acute myeloid leukemia (AML) and chronic lymphocytic (CLL) is very rare. We present a case simultaneous CLL AML in patient with no prior exposure to cytotoxic agents or irradiation.

1. Caballero MD, Gonzalez M, Canizo MC, Orfao A, Nieto MJ, San-Miguel JF. Concomitant chronic lymphocytic leukemia (CLL) and acute myeloid leukemia. Complete remission of CLL achieved with high-dose cytosine arabinoside. Leukemia 1992; 6:856-8. 2. Conlan MG, Mosher DF. Concomitant chronic lymphocytic leukemia, acute myeloid leukemia, and thrombosis with protein C deficiency. Case report and rev...

BACKGROUND The phosphatidylinositol-3-kinase/Akt pathway has been described to be critical in the survival of chronic lymphocytic leukemia cells. In this study we analyzed the effect of two selective chemical inhibitors of Akt (Akti-1/2 and A-443654) on the survival of chronic lymphocytic leukemia cells. DESIGN AND METHODS Using cytometry we studied the cytotoxic effects of Akt inhibitors on ...