Background: The prevalence of hepatitis B and C in Iranian children with chronic kidney disease is limited. Therefore, the present study intends to assess the prevalence of hepatitis B and C in children with chronic kidney disease (CKD).Method: The present study is a historical cohort study which was conducted in a window period of 25 years in Children’s Medical Center in Tehran, 1991-2016. Dat...

Background: Blood transfusion plays a great role in public health and the blood safety still has remained a main concern. HBV has been considered as one of the most prevalent blood borne infections. It is estimated that chronic HBV affects 350-400 million people worldwide. Comprehensive knowledge about HBV has high importance in Iran due to high number of blood dependent patients. Material ...

Background and Aims: Viral hepatitis is a global health problem with a high mortality rate. Recently, a new Flavi-like virus, provisionally named hepatitis G virus (HGV), has been described. HGV does not induce an immune response that is consistently detectable by using recombinant proteins from prokaryotic expression, therefore studies have been conducted by using polymerase chain reaction (...

background to estimate the total annual cost due to chronic hepatitis b (chb)-related diseases imposed on each patient and his/her family in iran.   methods economic burden of chb-related diseases (chb, cirrhosis, and hepatocellular carcinoma) were examined. in this retrospective study, 100 iranian patients were identified to obtain their socioeconomic status, utilization (direct and indirect c...

hepatitis b virus infection is a major public health problem worldwide. islamic republic of iran is a country in which hepatitisb prevalence is intermediate. the aim of this study is to assess prevalence of chronic hepatitis b infection in iran according to demographic characteristics. all cross-sectional studies concerning  revalence of chronic hepatitis b infection in iran were included irres...

context several risk factors play the role in the development of hepatocellular carcinoma (hcc) from which chronic hepatitis b and c infections are the most important ones. dna integration of hepatitis viruses alters the function of critical genes promoting malignant transformation of virus-infected liver cells. evidence acquisition there are remarkable geographic differences in prevalence of c...

introduction: hepatitis b is a potentially life-threatening infection that causes acute infection and chronic hepatitis with progression to cirrhosis and hepatocellular carcinoma (hcc). interleukin-12 (il12) is responsible for activation of th1 immune responses, leading to possible clearance of hbv infection from the host’s body. the host’s immune-genetic background plays an important role in t...

chronic hepatitis b is still a major public health issue despite the successful prophylactic vaccination attempts. chronicity of hepatitis b virus(hbv) is mainly due to its ability to debilitate host's immune system. therefore, major measures have been taken to stop this process and help patients with chronic hepatitis b infection recover from their illness. while satisfactory results have...

abstract   background: hepatitis b virus infection is an important cause of liver morbidity and mortality worldwide. hdv changes the natural course of hbv. the prevalence of hdv infection wasn’t determined in the various groups of hbv infection (carriers, acute hepatitis, chronic hepatitis, cirrhosis and hcc) in iran. we aimed to research the prevalence of hepatitis d virus infection in various...

Objective(s): Hepatitis B virus infection causes chronic disease such as cirrhosis and hepatocellular carcinoma. The metabolomics investigations have been demonstrated to be related to pathophysiologic mechanisms in many disorders such as hepatitis B infection. The aim of this study was to investigate the saliva metabolic profile of patients with chronic hepatitis B in...