background: about 15% of couples have infertility problems which 40% of them are related to the male factors. genetic factors are candidate for about 10% of male infertility conditions. among these, azfa, azfb, azfc and azfd regions on the yq are considered most important for spermatogenesis. microdeletions of these regions are thought to be involved in some cases of azoospermic or oligospermic...

Y chromosome microdeletions are the second genetic cause of male infertility. The incidence of Y chromosome microdeletions can vary considerably depending on several factors, including patient selection criteria, population composition, and diagnostic protocols. They are associated with spermatogenic failure and lead to azoospermia or oligozoospermia. The advance in assisted reproductive techno...

OBJECTIVE The aim of this study was to determine the frequencies of Y chromosome microdeletions in infertile azoospermic and oligozoospermic Turkish men and in healthy control subjects. MATERIAL AND METHODS Sixty-four azoospermic and 51 oligozoospermic patients infertile patients, and 70 healthy men who had a child without the aid of assisted reproductive technologies were included in this st...

Background The androgen receptor (AR) gene contains a polymorphic trinucleotide repeat that encodes a polyglutamine tract in its N-terminal transactivation domain (NTAD). We aimed to find a correlation between the length of this polymorphic tract and azoospermia or oligozoospermia in infertile men living in Khuzestan, Iran. MaterialsAndMethods In this case-control study during two years till 20...

Today, with advances in assisted reproductive techniques, many infertile couples are able to have children. However, there is always risk of passing genetic abnormalities associated with infertility from parents to children. Therefore, detection of microdeletions of Y chromosome in patients with spermatogenesis failure seems very important. The purpose of this study was to determine the frequen...

background: while multiple factors can contribute to male infertility, genetic factors, such as chromosomal disorders or y-chromosome microdeletion, are responsible for about 10% of male infertility. considering the role of y-chromosome microdeletions in men with oligozoospermia who volunteer for in vitro fertilization (ivf), the prevalence of such microdeletions in each particular community ne...

Objective: Advances in the science of genetics and development assisted reproductive techniques focus on genetic causes infertility. The aim this research is to reveal abnormalities terms sex chromosome aneuploidy Y microdeletions. Material Methods: A total 350 patients with azoospermia or severe oligozoospermia were selected. After general examination laboratory investigations performed, carto...

about 15% of couples have infertility problems, half of which are related to male factors. cytogenetic and genetic disorders account for about 10% of the male infertility problems. the aim of this study was to determine the frequency and types of both cytogenetic abnormalities and azf microdeletions of y chromosome in idiopathic azoospermic and oligospermic infertile men in west of iran. in thi...

INTRODUCTION We reviewed the most recent advances in the genetics of male infertility focusing on Y chromosome microdeletions. MATERIALS AND METHODS We searched the literature using the PubMed and skimmed articles published from January 1998 to October 2007. The keywords were the Y chromosome, microdeletions, male infertility, and azoospermia factor (AZF). The full texts of the relevant artic...