background: radioprotective capability of histamine h2 receptor antagonists have been shown in several in vivo studies mainly using animal models. however, to verify the effectiveness of these agents in clinical applications, studies should be performed on human cells. in the present study radioprotective properties of these agents was examined in vitro on human lymphocytes using metaphase anal...

introduction: infertility is a significant multifactorial disorder that can be caused by chromosomal abnormalities. in this study, we aimed to cytogenetically investigate male and female patients admitted to the genetic diagnostic laboratory of kayseri educational hospital in kayseri, turkey with varied clinical prediagnoses of infertility. materials and methods: chromosomes from cultured perip...

Chromosomal aberration is a phenomenon occurring relatively commonly in the development process. Chromosomal aberration is known to have various causes, and its frequency has been reported to vary particularly according to maternal age. Though different among reports, the frequency was around 0.6-0.8% in analysis with all childbirths1 and around 2-3% in case childbirths were reclassified based ...

The present investigation was undertaken to explore the Antimutagenicity activity of Terminalia chebula on micronucleus formation and chromosomal aberration assay in bone marrow cells of Swiss albino mice. The protective effect of Terminalia chebula extract is reported against cyclophosphamide (CP)-induced micronuclei formation and chromosomal aberration in mouse bone marrow cells. The doses na...

background: cirrhinus mrigala, one of the important fish widely consumed in india, was used for karyological observations and to evaluate the toxic effect of butachlor, an extensively used herbicide in rice fields in terms of chromosomal aberration test. methods: fishes were collected from “national fish seed farm” jyotisar with mean body weight of 20-50g. the experimental fishes were kept in t...

total or partial absence or excess of the sex chromosomes produces different karyotypes and phenotypical abnormalities. upon retrospective analysis of the results of 163444 cytogenetic tests that were performed during 28 years (1987-2015) in this center, different types of sex chromosomal aberrations and the clinical phenotypes are delineated in this article. moreover, the clinical course and t...

purpose: the aim of this study was to test the in vitro sensitivity of lymphocytes of patients with head and neck cancer against gamma irradiation and also to find out if the frequencies of chromosomal aberrations correlate with side effects of radiotherapy. patients and methods : peripheral blood of 101 patients with head and neck cancer was collected before the onset of radiotherapy, cultured...

normal sex differentiation is the result of long ways and different steps that consecutively take place under the control of relevant enzymes resulting in a normal female or male. any effective agent and excess or deficit of the relevant enzymes result in the disorder of sex development. the main factors that affect sex development include chromosomal aberration, gonadal dysgenesis, and hormona...

The frequency of chromosomal aberrations was studied in the peripheral blood lymphocytes of 65 radiology technologists CRT) working at hospitals chronically exposed to x-rays. Although film dosimetry did not show the maximal annual permitted dose in any of the examined subjects, cytogenetic analysis detected fairly high levels of chromosomal aberrations in R T compared to unexposed controls...