9. Bonifaz A, Martinez-Soto E, Carrasco-Gerard E, Peniche J. Treatment of chromoblastomycosis with itraconazole, cryosurgery, and a combination of both. Int J Dermatol. 1997;36: 542--7. 10. Kullavanijaya P, Rojanavanich V. Successful treatment of chromoblastomycosis due to Fonsecaea pedrosoi by the combination of itraconazole and cryotherapy. Int J Dermatol. 1995;34: 804--7. J. Bassas-Vila,∗ M....

Chromoblastomycosis is a chronic, subcutaneous mycosis, characterized by verrucous nodular lesions, usually involving the legs and mainly caused by Fonsecaea, Phialophora, and Cladophialophora spp. The characteristic finding on direct examination or biopsy specimen is the presence of fumagoid cells or Medlar bodies. Chromoblastomycosis can be refractory to medical treatment. Therapeutic options...

Chromoblastomycosis is a subcutaneous mycosis caused by the dermatophytic fungi Fonsecaea, Phialophora and Cladophialophora. Usual complications include secondary infection, lymphedema and elephantiasis. Associated malignancies have been found in chronic cases. This case report describes a 72 year-old male with a 30 year history of chromoblastomycosis in the gluteal region, who went on to devel...

Chromoblastomycosis is a chronic fungal infection of the epidermis, dermis and subcutaneous tissue, in which the most common etiologic agent in Brazil is Fonsecaea pedrosoi. In more advanced cases we found many difficulties in their treatment, and therefore, we report a case of extensive and severe chromoblastomycosis, with therapeutical failure of first choice treatments, but good response to ...

OBJECTIVES A murine model of chromoblastomycosis caused by Cladophialophora carrionii was used to compare the efficacy of posaconazole and voriconazole with that of terbinafine and itraconazole, the currently used drugs in the management of chromoblastomycosis. METHODS Athymic nude mice were infected with 2 × 10(7) cfu of a clinical isolate of C. carrionii. When typical lesions were establish...

We report a case of borderline lepromatous leprosy with chromoblastomycosis, in view of the rarity of such a clinical presentation and to highlight the coexistence of two granulomatous infections. Chromoblastomycosis presents as verrucous lesions that are usually localised to the skin and subcutaneous tissue, most commonly on the legs and feet, and may spread along lymphatics [causing elephanti...

Fonsecaea pedrosoi is the most prevalent aetiological agent of chromoblastomycosis. Fonsecaea monophora is a new species segregated from Fonsecaea pedrosoi. Herein, we report on three cases of chromoblastomycosis caused by F. monophora that were successfully treated with terbinafine and/or itraconazole. Clinical characteristics and mycological parameters are described. Two of the three patients...

There was no specific treatment for chromoblastomycosis until 5-fluorocytosine became available. A number of different drugs and therapeutic procedures were used for this mycosis, but none had proved absolutely effective. The first cases of successful treatment of chromoblastomycosis using 5-fluorocytosine, substantiated by monitored results, were reported by Lopes and colleagues (10, 11, 12, 1...

The host defense mechanism in chromoblastomycosis has not been thoroughly investigated. It has been suggested that cell-mediated immunity in patients with long-standing chromoblastomycosis is somehow impaired. As a result, these individuals became unable to develop an efficient immune reaction. Many studies have shown that monocyte-derived macrophages exhibit critical activities in immunity to ...

Sir, Chromoblastomycosis is a chronic cutaneous and subcutaneous infection due to a group of dematiaceous fungi including Fonsecaea pedrosoi, Cladophialophora carrionii, Phialophora verrucosa, F. compacta and Rhinocladiella aquaspersa (1). This infection occurs in tropical and subtropical regions and results from traumatic implantation of material contaminated by the fungus (1, 2). We report he...