background: a simple and sensitive high performance liquid chromatography-electrospray ionization mass spectrometry method has been evaluated for the assignment of clonidine hydrochloride in human plasma. methods: the mobile phase composed of acetonitrile-water 60:40 (v/v) and 0.2% formic acid 20 µl of sample was chromatographically analyzed using a repacked zorbax-xdb-ods c18 column (2.1 mmx30...

effects of temperature and percentage of organic modifier were studied on retention and selectivity in rp-hplc using solvation parameter model. the system constants were determined by multiple linear regression analysis from experimental values in the retention factor for a group of different solutes with known descriptors by computer using the program spss/pc. the experimental results showed t...

effects of temperature and percentage of organic modifier were studied on retention and selectivity in rp-hplc using solvation parameter model. the system constants were determined by multiple linear regression analysis from experimental values in the retention factor for a group of different solutes with known descriptors by computer using the program spss/pc. the experimental results showed t...

conclusions this method could be feasibly used for purification of large quantities of allicin from garlic extract. results semi-preparative hplc yielded a distinct peak with a retention time of 12.28 minutes. the purity (≥ 95%) and biological activity (p > 0.05) of purified allicin were comparable to the standard allicin. purified allicin produced same peak areas compared to the standard allic...

in the present study, a comprehensive and systematic strategy was described to evaluate the performance of several three-way calibration methods on a bio-analytical problem. parallel factor analysis (parafac), alternating trilinear decomposition (atld), self-weighted alternating trilinear decomposition (swatld), alternating penalty trilinear decomposition (aptld) and unfolded partial least squa...

a stability indicating high-performance liquid chromatography (hplc) method wasvalidated and used to study the degradation of cetirizine dihydrochloride in acidic and oxidativeconditions. the separation was carried out on a symmetry c18 column and a mixture of 50 mmkh2po4 and acetonitrile (60:40 v/v, ph = 3.5) was used as the mobile phase. the method waslinear over the range of 1-20 μg/ml of ce...

background: cattle can be considered as an important source for herbicides through nutrition. therefore, herbicide residue in animal products is a potential human exposure to herbicides causing public health problems in human life. triazines are a group of herbicides primarily used to control broadleaf weeds in corn and other feed ingredients and are considered as possible human carcinogens. to...

conclusions examination of the fasting lipid profile has clinical importance in predicting the efficacy of peg-ifn-α-2b plus rbv combination therapy for patients with hcv g1b even after the discovery of the il28 genotype as a potent predictive factor. objectives to re-examine the significance of lipoprotein profiles on virological response to peg-ifn plus rbv combination therapy in patients wit...