PURPOSE To assess the detection efficiency of Half-Fourier acquisition single-shot turbo spin-echo (HASTE) diffusion-weighted magnetic resonance imaging (MRI) for cholesteatoma. MATERIALS AND METHODS A total of 21 patients with suspected primary (n=16) or recurrent cholesteatoma (n=5) underwent MRI in a 1.5 Tesla scanner using an adapted protocol for cholesteatoma detection that included a co...

OBJECTIVE To evaluate the accuracy and sensitivity of diffusion-weighted magnetic resonance imaging with ADC value combined with MDCT in evaluating recurrent cholesteatoma. PATIENTS Thirty patients (20 females and 10 males), their age ranged from 10 to 40years, had undergone a tympanomastoid surgery for a cholesteatoma of the middle ear underwent MDCT and MR DWI examination before second- or ...

Introduction: Cholesteatoma is traditionally diagnosed by otoscopic examination and treated by surgery. The necessity for imaging in an uncomplicated case is controversial. This study was planned to investigate the usefulness of a preoperative high-resolution computed tomography (HRCT) scan in depicting the status of middle ear structures in the presence of cholesteatoma and also to compare the...

OBJECTIVE To assess the advantages and disadvantages of using endoscopic technique in the management of cholesteatoma. STUDY DESIGN Retrospective case review. SETTING Private otology practice. PATIENTS Patients with cholesteatoma of the temporal bone presenting over a 16-year period to a single otologist. INTERVENTION(S) Primary endoscopic surgery for removal of the cholesteatoma and fu...

OBJECTIVES Cholesteatoma is a nonneoplastic destructive lesion of the temporal bone with debated pathogenesis and bone resorptive mechanism. Both molecular and cellular events chiefly master its activity. Continued research is necessary to clarify factors related to its aggressiveness. We aimed to investigate the expression of Ki-67, cytokeratin 13 (CK13) and cytokeratin 17 (CK17) in acquired n...

Background: We are taught that cholesteatoma occurs due to tympanic membrane retraction that is usually secondary to eustachian tube dysfunction. Many children with poor eustachian tube dysfunction get tubes, which has been described as an independent cause of cholesteatoma. Objective: To describe the risk factors for cholesteatoma in children with tympanostomy types. Design: Retrospective revi...

OBJECTIVES Experimental models are of importance to study the pathogenesis of middle ear cholesteatoma, however, they were not established until now. We aimed to develop in vitro model of middle ear cholesteatoma using primary keratinocytes and fibroblasts isolated from cholesteatoma tissue. HaCaT cell line was used as a "skin equivalent" and to compare the grade of homogeneity between choleste...

OBJECTIVES/HYPOTHESIS To identify factors associated with the rate of developing cholesteatoma following ventilation tube insertion (VTI). STUDY DESIGN A population-based retrospective cohort study. METHODS Administrative health data from all private and public hospitals in Western Australia for children who had at least one VTI from 1980 to 2004 was used to identify subsequent hospital adm...

Triggering receptor expressed on myeloid cells (TREM) has been broadly studied in inflammatory disease. However, the expression and function of TREM-2 remain undiscovered in acquired cholesteatoma. The expression of TREM-2 was significantly higher in human acquired cholesteatoma than in normal skin from the external auditory canal, and its expression level was positively correlated with the sev...

BACKGROUND AND OBJECTIVES The aim of this study is to determine whether the hyperproliferative and hyperkeratotic characters of cholesteatoma are associated with differentiation of keratinocytes in cholesteatoma by examining the localization of marker proteins, such as involucrin, filaggrin, and cytokeratins. MATERIALS AND METHODS Immunohistochemical study was carried out in 30 cholesteatoma ...