Chlamydiae are obligate intracellular pathogens replicating only inside the eukaryotic host. Here, we studied the effect of human flotillin-1 protein on Chlamydia pneumoniae growth in human line (HL) and A549 epithelial cell lines. RNA interference was applied to disrupt flotillin-1-mediated endocytosis. Host-associated bacteria were detected by quantitative PCR, and C. pneumoniae growth was ev...

OBJECTIVE To examine whether reactive arthritis (ReA) known to occur after a urogenital infection with Chlamydia trachomatis can also follow an infection with Chlamydia pneumoniae, a recently described species of Chlamydiae that is a common cause of respiratory tract infections. METHODS Specific antibodies (microimmunofluorescence test) and lymphocyte proliferation to C trachomatis and C pneu...

The pulmonary histopathologic features in a sporadic case of Legionnaires' disease are shown. The changes include acute bronchitis with focal ulceration and diffuse acute interstitial pneumonitis. These changes are not those seen with typical bacterial pneumonia but are similar to changes seen when viruses, rickettsiae, chlamydiae, or Mycoplasma pneumoniae organisms are the infecting agents.

Among the many theories of the pathogenesis of atherosclerosis has been a possible role for infection. However, the possibility that a viral infection initiates or perpetuates damage to the arterial wall has received less attention than other more widely recognized risk factors. Recently, a newly described Chlamydia species, Chlamydia pneumoniae, strain TWAR,' has been associated with atheroscl...

Chlamydiae are intracellular bacteria that develop within a membrane-bound vacuole called an inclusion. To ensure that the inclusion is a safe niche for chlamydial replication, chlamydiae exploit a number of host cell processes, including membrane-trafficking pathways. Recently, several Rab GTPases were found to associate with the inclusions of various chlamydial species. Here we report that Cp...

Chlamydiae are intracellular, gram-negative, and prokaryotic microorganisms. Capable of causing disease in many mammalian avian species, there three types that cause humans: Chlamydia trachomatis, pneumoniae, psittaci. Among the chlamydia C. trachomatis is most studied encountered type because it a leading trachoma sexually transmitted diseases. known pathogen genital tract, can also be routine...

A driving force in the evolution of a microorganism is the ability to colonize a niche. A vertebrate organism represents a unique niche, but to an infecting microbe it is simply an environment to be exploited. Many pathogens explore yet another opportunity—the intracellular environment. The chlamydiae are obligate intracellular pathogens that have established a unique niche within the host cell...

Chlamydiae are important pathogens of a range of birds and animals including sheep, cattle, pigs, cats, goats, koalas, other Australian marsupials, amphibians and reptiles. Recent changes to chlamydial taxonomy has seen the proposal of two genera, Chlamydia/Chlamydophila with nine species – C trachomatis, C muridarum, C suis, C psittaci, C pecorum, C abortus, C caveae, C felis and C pneumoniae ...

The pathogenesis of primary pulmonary hypertension is still unclear. The case of a 68-yr-old female patient who complained of recurrent dizzy spells and collapses over a period of 6 weeks and died of global cardiac failure is presented. Autopsy revealed severe pulmonary hypertension, slight chronic bronchitis, and bronchiolitis as well as intra-alveolar accumulation of macrophages. Chlamydiae w...

The activity of grepafloxacin, a new orally active fluoroquinolone, was compared with the activities of ofloxacin, clarithromycin and doxycycline against Chlamydia pneumoniae, Chlamydia trachomatis, Mycoplasma pneumoniae, Mycoplasma hominis and Ureaplasma urealyticum, and with the activities of ofloxacin, clarithromycin and rifampicin against Legionella spp. Grepafloxacin (MIC range 0.06-0.12 m...