نتایج جستجو برای: chitosan nanocapsules and cytotoxicity

تعداد نتایج: 16836846  

2016
Laura De Matteis Maria Alleva Inés Serrano-Sevilla Sonia García-Embid Grazyna Stepien María Moros Jesús M. de la Fuente

The tunability of the properties of chitosan-based carriers opens new ways for the application of drugs with low water-stability or high adverse effects. In this work, the combination of a nanoemulsion with a chitosan hydrogel coating and the following poly (ethylene glycol) (PEG) grafting is proven to be a promising strategy to obtain a flexible and versatile nanocarrier with an improved stabi...

Journal: :modares journal of medical sciences: pathobiology 2014
yousef masti mojtaba saadsti shahram nazarian mahdi fasihi ramandi morteza asadi

objectives: ctxb (cholera toxin b subunit) contributes to a vaccine's efficacy by stimulating production of the anti-ctxb antibody. various attempts have been made to increase production of this antibody. chitosan is a mucoadhesive polysaccharide that has tremendous potential for oral vaccine delivery in terms of its exclusive features that include biocompatibility, biodegradability, high charg...

2008
Kun-Ho Liu San-Yuan Chen Dean-Mo Liu Tse-Ying Liu

A new type of amphiphilic chitosan, which was synthesized through the use of both hydrophilic carboxymethyl and hydrophobic hexanoyl substitutions, was employed to self-assemble into a hollow nanocapsule in an aqueous environment. Critical aggregation concentration (cac) and zeta potential were experimentally identified for the amphiphilic chitosan (CHC). Both experimental data suggested that t...

Journal: :The Journal of antimicrobial chemotherapy 2013
Divya Prakash Gnanadhas Midhun Ben Thomas Monalisha Elango Ashok M Raichur Dipshikha Chakravortty

OBJECTIVES The ability to target conventional drugs efficiently inside cells to kill intraphagosomal bacteria has been a major hurdle in treatment of infective diseases. We aimed to develop an efficient drug delivery system for combating infection caused by Salmonella, a well-known intracellular and intraphagosomal pathogen. Chitosan-dextran sulphate (CD) nanocapsules were assessed for their ef...

Journal: :International journal of biological macromolecules 2015
Melissa C Rivera Ana C Pinheiro Ana I Bourbon Miguel A Cerqueira António A Vicente

This work aimed at the development of biodegradable nanocapsules as carriers of two bioactive compounds, 5-aminosalycilic acid and glycomacropeptide. Nanocapsules were produced through layer-by-layer (LbL) deposition of chitosan (CH) and alginate (ALG) layers on polystyrene nanoparticles. The bioactive compounds were incorporated on the third layer of the nanocapsules being its encapsulation ef...

Journal: :journal of paramedical sciences 0
elham malakooty poor department of stem cells and developmental biology at cell sciences research center, royan institute for stem cell biology and technology, acecr, tehran mohamadreza baghaban eslaminejad department of stem cells and developmental biology at cell sciences research center, royan institute for stem cell biology and technology, acecr, tehran fatemeh bagheri department of stem cells and developmental biology at cell sciences research center, royan institute for stem cell biology and technology, acecr, tehran esmail mollarazi department of nuclear pharmacy, faculty of pharmacy, tehran university of medical sciences,tehran nematollah gheibi cellular and molecular research center,qazvin university of medical sciences, qazvin

this study discusses the effect of complexes of chitosan grafted polyethylenimine(ch-pei) with plasmid dna on viability of mesenchymal stem cells(mscs) derived from human marrow. ch-pei/pdna nanoparticles were synthesized through the complex coacervation method using pires plasmid containing green fluorescent protein (gfp) gene. to confirm the complexation, samples were run through an agarose g...

2015
Hale Ünal Naile Öztürk Erem Bilensoy

BACKGROUND The aim of this study was to design and evaluate hybrid cyclodextrin (CD) nanocapsules intended for the oral delivery of the anticancer agent camptothecin (CPT) in order to maintain drug stability in the body and to improve its eventual bioavailability. For this reason, an amphiphilic cyclodextrin (CD) derivative per-modified on the primary face 6OCAPRO was used as core molecule to f...

Journal: :Molecular cancer therapeutics 2006
Irene H L Hamelers Esther van Loenen Rutger W H M Staffhorst Ben de Kruijff Anton I P M de Kroon

Platinum-based drugs are widely used in cancer chemotherapy. However, their clinical use is limited by systemic toxicity, rapid blood clearance, and the occurrence of resistance. Our research is aimed at increasing the therapeutic index of these drugs by encapsulation in a lipid formulation. Previously, we developed a method for efficient encapsulation of cisplatin in a lipid formulation, yield...

Journal: :nanomedicine journal 0
esmaeil mirzaei department of medical nanotechnology, school of advanced medical technologies, tehran university of medicalsciences, tehran, iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (tehran university of medical sciences) reza faridi-majidi department of medical nanotechnology, school of advanced medical technologies, tehran university of medicalsciences, tehran, iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (tehran university of medical sciences) mohammad ali shokrgozar national cell bank of iran, pasteur institute of iran, tehran, iranسازمان اصلی تایید شده: انستیتو پاستور ایران (pasteur institute of iran) farnoush asghari paskiabi department of medical nanotechnology, school of advanced medical technologies, tehran university of medicalsciences, tehran, iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (tehran university of medical sciences)

objective(s): to improve water stability of electrospun chitosan/ polyethylene oxide (peo) nanofibers, genipin, a biocompatible and nontoxic agent, was used to crosslink chitosan based nanofibers.  materials and methods: different amounts of genipin were added to the chitosan/peo solutions, chitosan/peo weight ratio 90/10 in 80 % acetic acid, and the solutions were then electrospun to form nano...

Journal: :ACS nano 2010
Yu Chen Hangrong Chen Deping Zeng Yunbo Tian Feng Chen Jingwei Feng Jianlin Shi

A potential platform for simultaneous anticancer drug delivery and MRI cell imaging has been demonstrated by uniform hollow inorganic core/shell structured multifunctional mesoporous nanocapsules, which are composed of functional inorganic (Fe(3)O(4), Au, etc.) nanocrystals as cores, a thin mesoporous silica shell, and a huge cavity in between. The synthetic strategy for the creation of huge ca...

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