in recent years, chitosan nanoparticles have been studied widely for protein delivery. in this study, hemiscorpius lepturus (hl) venom was encapsulated in chitosan nanoparticles. the aim of the present work was to carry out a systematic study for preparing biocompatible and biodegradable nanoparticles for loading hl scorpion venom and to evaluate their potential as an antigen delivery system. i...

objective(s): nanoparticles (nps) are known for their specific accumulation in the inflamed tissues of the colon and thus allow a selective delivery to the site of inflammation with minimum adverse effects. the main objective of this work is to attain mesalamine loaded chitosan nanoparticles as a carrier for oral delivery. methods: in this study, mesalamine loaded chitosan nanoparticles were pr...

alzheimer's disease (ad) is a progressive neurodegenerative disease characterized by memory and cognitive dysfunction due to neuronal cell loss in higher brain centers. senile plaques containing amyloid β (aβ) are associated with this disease as well as a reduction in cholinergic neuron numbers. tacrine is a reversible cholinesterase inhibitor in clinical use to treat moderate forms of ad. chit...

Polyelectrolyte-coated nanoparticles or microparticles interact with bioactive molecules (peptides, proteins or nucleic acids) and have been proposed as delivery systems for these molecules. However, the mechanism of adsorption of polyelectrolyte onto particles remains unsolved. In this study, cationic poly(lactide-co-glycolide) (PLGA) nanoparticles were fabricated by adsorption of various conc...

background: influenza outbreak has become a great lifethreateningdisease in the world. nasal vaccines can inducesystemic igg and mucosal iga antibody responses, whichestablish two layers of immune defense against the infectiouspathogens like influenza. mucosal vaccines must overcomeseveral limitations, including the mucociliary clearance andinefficient uptake of soluble antigens. therefore, nas...

BACKGROUND: Influenza outbreak has become a great lifethreateningdisease in the world. Nasal vaccines can inducesystemic IgG and mucosal IgA antibody responses, whichestablish two layers of immune defense against the infectiouspathogens like influenza. Mucosal vaccines must overcomeseveral limitations, including the mucociliary clearance andinefficient uptake of soluble antigens. Therefore, nas...

BACKGROUND Although there are a number of reports regarding the toxicity evaluation of inorganic nanoparticles, knowledge on biodegradable nanomaterials, which have always been considered safe, is still limited. For example, the toxicity of chitosan nanoparticles, one of the most widely used drug/gene delivery vehicles, is largely unknown. In the present study, the zebrafish model was used for ...

BACKGROUND Chitosan nanoparticles have become of great interest for nanomedicine, biomedical engineering and development of new therapeutic drug release systems with improved bioavailability, increased specificity and sensitivity, and reduced pharmacological toxicity. The aim of the present study was to synthesis and optimize of the chitosan nanoparticles for industrial and biomedical applicati...

in this paper, fe3o4-chitosan nanoparticles were prepared by the immobilization of chitosan on the surface of fe3o4 nanoparticles. then, the 5-substituted hydantoins were synthesized from the condensation of aldehyde derivatives, ammonium carbonate and zinc cyanide as a well-known cyanating agent by the magnetic fe3o4-chitosan nanoparticles under neat conditions. fe3o4-chitosan nanocatalyst as ...