In this paper a novel capillary electrophoresis chip (CEC) is presented with integrated platinum electrodes and simplified conductivity detector. CEC is fabricated by the method of mechanical modification with probe on organic glass. Capillary electrophoresis chip can rapidly completed ion separation by simulation of concentration distribution and zonebroadening. Detection circuit is simple whi...

We developed an inkjet-based DNA injector for microchip electrophoresis system based on a straight microchannel. The inkjet-based DNA injector enables us to precisely control injection volume of DNA and to use a simple straight microchannel for chip electrophoresis, whereas we need cross channel injector or T injector as well as complicated voltage programming for conventional chip electrophore...

This work presents patterning of thick (10–50 μm) hybrid polymer structures of ORMOCER by laser direct writing. ORMOCER combine polymer-like fabrication processes with glass-like surface chemistry that is beneficial for many bio-microfluidic applications. ORMOCER is liquid before exposure, so patterning is done by contact-free lithography, such as proximity exposure. With laser direct writing, ...

In this paper, we describe the design and performance of two digital microfluidics (DMF) chips capable executing multiple ribozymatic reactions, with proper controls, in response to short single-stranded DNA inducers. Since fluorescence output a reaction is measurable directly from chip, without need for gel electrophoresis, complete experiment involving up eight reactions (per chip) can be car...

Microalbuminuria reflects the progression of nephropathy and cardiovascular disease in diabetic and hypertensive patients. Most commercially available tests currently used to measure microalbuminuria are immunoassays. We developed a microfluidics-based assay using the P200 protein chip (Caliper Life Sciences, Mountain View, CA, and Agilent Technologies, Santa Clara, CA) and 2100 Bioanalyzer (Ag...

Miniaturized, portable instrumentation has been gaining popularity in all areas of analytical chemistry. Capillary electrophoresis (CE), due to its main strengths of high separation efficiency, relatively short analysis time and low consumption of chemicals, is a particularly suitable technique for use in portable analytical instrumentation. In line with the general trend in miniaturization in ...