In recent years, numerous studies have been performed to identify biomarkers that predict prognosis or response to chemother-Non-small cell lung cancer represents one example where expression profiling was used to successfully identify prog-nostic signatures (Wigle et al. assist in the decision whether patients should receive adjuvant chemotherapy after surgical resection. A recently published ...

Published by Kowsar. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The globally increasing incidence of cancer and its associated mortality has become a main challenge for humankind. This problem is more serious in ...

which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Two well defined mutations, including the NPM1 and CCAAT/enhancer-binding protein-alpha (CEBPA) genes, are generally accepted as a better prognosis in AML [1]. NPM1, one of frequent mutations in AML, have been described in association with several clinical f...

In a paper published in the present issue of Haema-tologica, 1 Guidetti et al. investigate the clonal origin of hematopoietic cells in patients with myelodysplastic syndromes (MDS). Several cell populations were analyzed , including peripheral blood granulocytes and T lymphocytes, bone marrow hematopoietic progenitors (CFU-GM and BFU-E) and long-term culture-initiating cells (LTC-IC), which rep...

SUMMARY Preliminary clinical studies have been reported suggesting an increased response rate to a five-drug combination program in lung cancer patients who were anticoagulated with heparin. This study was undertaken to determine the effect of heparin on the cytotoxicity and cellular drug uptake of four antineoplastic agents. Burkitt lymphoma cells (P3J) in continuous culture were incubated wit...

The purpose of this guideline is to assist nuclear medicine practitioners in recommending, performing , interpreting, and reporting hepatic and splenic imaging studies. A. Liver–spleen imaging is performed after the injection of a 9 9 m Tc-labeled colloid that has been rapidly phagocytized by the reticuloendothelial cells of the liver, spleen, and bone marrow. B. Liver blood pool imaging is per...

P rotein kinases regulate a vast array of cellular processes including, but not limited to, cell proliferation, differentiation , motility, death, and survival. They regulate these and other processes by attaching phosphate groups onto various proteins (substrates), changing the substrate's activity, sub-cellular localization, and resistance to (or promotion of) cell death. There are Ͼ500 kinas...

Primary cardiac tumours are quite rare. Only 7 cases were reported in a series of 12,000 autopsies, and its prevalence is less than 0.1% [1]. Malignant tumours account for approximately 15% of primary cardiac tumours, and sarco-mas are the most common [2]. Cardiac sarcomas are quite rare and have been published as isolated case reports. Rhabdomyosarcomas account for 20% of overall cardiac sarco...

Editor's Note: These short, critical reviews of recent papers in the Journal, written exclusively by graduate students or postdoctoral fellows, are intended to summarize the important findings of the paper and provide additional insight and commentary. For more information on the format and purpose of the Journal Club, please see Review of Wei et al. Neuropathic pain is an important public heal...

xercise is good for everyone, even patients who are undergoing treatment for cancer or who are recovering from cancer treatment. However, this was not always obvious. In 1988, Meryl Winningham rocked the cancer community with her groundbreaking series of studies of women undergoing chemothera-py for breast cancer. Women who were randomized to a bicycle exercise group experienced less chemothera...