Chemokine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Receptors [438, 437, 32]) comprise a large subfamily of 7TM proteins that bind one or more chemokines, family small cytokines typically possessing chemotactic activity for leukocytes. Additional hematopoietic and non-hematopoietic roles have been identified many chemokines in areas embryonic development, immune cell pr...

not been systematically examined. Similar clustering has C been observed among genes encoding chemokine receptors. HEMOKINES have recently become the focus of intense interest and discussion. This has occurred, in One exception to the CC/CXC rule is lymphotactin, a part, because of an enlarging view of what chemokines do. potent attractant for T lymphocytes, but not monocytes. As recently as 2 ...

inflammatory condition is the consequence of defensive mechanism of immune system against viral and bacterial infection, tissue injury, uv radiation, stress and etc. persistently acute inflammation leads to chronic phase which is characterized by production of pro-inflammatory mediators from t cells. these molecules (e.g. il-6, tnf-α, il-1β and il-17) are mostly pleiotropic cytokines involved i...

Human memory CD4(+) T cells respond better to inflammatory CCLs/CC chemokines, CCL3 and CCL5, than naive CD4(+) T cells. We analyzed the regulatory mechanism underlying this difference. Memory and naive CD4(+) T cells expressed similarly high levels of CCR1; however, CCR5 was only expressed in memory CD4(+) T cells at low levels. Experiments using mAbs to block chemokine receptors revealed that...