(ATX or ENPP2) was isolated as an autocrine motility factor from melanoma cells. 1 The ∼120 kDa glycoprotein ATX belongs to a small family named ectonucleotide pyrophosphatase and phosphodiesterase (ENPP), which consists of seven family members. 2 ATX is the only ENPP family member with lysophospholipase D (lysoPLD) activity and is responsible for the hydrolysis of lysophosphatidylcholine (LPC)...

To protect materials against biodeterioration, physical, biological or chemical methods can be used. Chemical inhibitors of biodeterioration are the most common and effective. A new class of chemical inhibitors-gemini alkylammonium salts-shows excellent biocidal properties and good ecological profile. These compounds can be applied as biodeterioration inhibitors in a wide variety of materials.

One of the most important targets in Alzheimer disease is Beta site amyloid precursor protein cleaving enzyme-1 (BACE-1). It is a membrane associated protein and is one of the main enzymes responsible for amyloid β (Aβ) production. Up to now, a considerable number of peptidic and non-peptidic inhibitors of BACE-1 have been developed. Recently, small molecule BACE-1 inhibitors have attracted the...

One of the most important targets in Alzheimer disease is Beta site amyloid precursor protein cleaving enzyme-1 (BACE-1). It is a membrane associated protein and is one of the main enzymes responsible for amyloid β (Aβ) production. Up to now, a considerable number of peptidic and non-peptidic inhibitors of BACE-1 have been developed. Recently, small molecule BACE-1 inhibitors have attracted the...

a fundamental study of scale formation of calcium carbonate (caco3) for producing oil wells hasbeen carried out. this article presents the study of the prediction of salt deposition in two differentsynthetic formation waters and investigates the effects of temperature and pressure on calciumcarbonate precipitation. the dependence of the induction period of the precipitation of calciumcarbonate ...

one of the most important targets in alzheimer disease is beta site amyloid precursor protein cleaving enzyme-1 (bace-1). it is a membrane associated protein and is one of the main enzymes responsible for amyloid β (aβ) production. up to now, a considerable number of peptidic and non-peptidic inhibitors of bace-1 have been developed. recently, small molecule bace-1 inhibitors have attracted the...

The inhibition performances of nafcillin (III), methicillin (II) and penicillin G (I) on the corrosion of copper in HCl was studied and tested by weight loss, Tafel polarization, SEM, UV-vis spectrophotometry, molecular dynamics method and quantum chemical calculations. Polarization curves indicated that the studied inhibitors act as mixed-type inhibitors. The values of inhibition efficiency an...

the urgent need of neuraminidase inhibitors (ni) has provided an impetus for understanding the structure requisite at molecular level. our search for selective inhibitors of neuraminidase has led to the identification of pharmacophoric requirements at various positions around acyl thiourea pharmacophore. the main objective of present study is to develop selective ni, with least toxicity and dru...