Recently, some evidence has shown that the failure of iron homeostasis may occur in critically ill patients and can lead to iron overload. Elevated ferritin levels as a body iron burden index in critically ill patients may be associated with depressed level of consciousness and greater mortality. However, the necessity of using iron-chelating agents in clinical situation is still unknown for th...

The successful design of orally active non-toxic selective metal chelators is a much sought-after goal. In order to identify an ideal chelator for clinical use, a range of specifications must be considered, such as metal selectivity and affinity, kinetic stability of the complex, bioavailability and toxicity. In this overview the comparative properties of ligands capable of endowing complexes w...

Chelation enables metals to be transported to or from vulnerable target sites, and to hinder or facilitate their carcinogenic potential. In the reverse sense, metals are capable of ligand scavenging via complexation or mixed complex formation--the latter being the result of interaction with binary complexes. Consequently, metal complexes can be utilized for the transport of selected organic che...

Present study shows the Rationale behind the synthesis of chelating agents and their thermodynamic stability along with kinetic inertness of metal complex in vivo is the prerequisites for the successful application of bifunctional chelating agentconjugate. Macrocyclic bifunctional chelating agents (BFCs) with their established stabilizing properties are in the forefront for radio-immuno applica...

hepatitis is the infections of a common cause disease among poly transfused patients. hepatitis c is slowed progression and inducing hcc. this study assessed hcc incidences, the role of iron and possible antitumor activity of chelators in 170 thalassemia patients using deferoxamine (dfo) therapy. they are diagnosed with hepatitis c due to positive pcr-rna. they are treated with ifn. the follow ...

It was reported in previous studies that inhibitory concentrations of certain chelating or complexing agents did not inhibit several microorganisms when these agents were tested simultaneously (Feeney, 1951; Feeney and Nagy, 1952). Amounts of the metal-binding agents which were strongly inhibitory when tested alone were necessary in order to obtain these mutual preventions of inhibitory action....