The metabolism of benzo(a)pyrene (BaP) by hepatic or cheek pouch epithelium microsomes obtained from Syrian golden ham sters which had been consuming an ethanol-containing liquid diet for 4 wk and from pair-fed controls was measured. Gluta thione S-transferase activity with 1-chloro-2,4-dinitrobenzene or (±)-r-7,f-8-dihydroxy-f-9,10-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene as substrates was mea...

The goal of this study was to investigate the role of cytochrome P-450 ω-hydroxylase in mediating O2-induced constriction of arterioles in the microcirculation of the hamster. Male Golden hamsters were anesthetized with pentobarbital sodium, and the cremaster muscle or cheek pouch was prepared for observation by intravital microscopy. Arteriolar diameters were measured during elevations of supe...

The metabolism of benzo(a)pyrene (BaP) by hepatic or cheek pouch epithelium microsomes obtained from Syrian golden hamsters which had been consuming an ethanol-containing liquid diet for 4 wk and from pair-fed controls was measured. Glutathione S-transferase activity with 1-chloro-2,4-dinitrobenzene or (+/-)-r-7,t-8-dihydroxy-t-9,10-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene as substrates was meas...

The adaptive function of cheek pouches in the primate subfamily Cercopithecinae remains unresolved. By analyzing the circumstances of cheek pouch use, we tested two hypotheses for the evolution of cercopithecine cheek pouches proposed in earlier studies: (1) cheek pouches reduce vulnerability to predation, and (2) cheek pouches increase feeding efficiency by reducing competition. We studied two...

The responses to changes in transmural pressure were investigated in pulmonary allograft and cheek pouch arterioles in two oxygen environments. Neonatal hamster lung tissue was transplanted into adult hamster cheek pouches. After vascularization (8-10 days), pulmonary and cheek pouch vessels were observed by intravital microscopy in hamsters anesthetized with pentobarbital. By gassing the suffu...

The purpose of this study was to determine whether inhibitors of tyrosine kinase attenuate vasodilation elicited by endogenously elaborated and exogenously applied nitric oxide in the in situ peripheral microcirculation. Using intravital microscopy, we found that pretreatment with genistein (1.0 microM) and tyrphostin 25 (10.0 microM), two structurally unrelated tyrosine kinase inhibitors, sign...

or pieces of endometrium to the cheek pouch of hysterectomized animals significantly reduces the length of induced pseudopregnancy from 18 to 13\m=.\5 days (Caldwell, Mazer & Wright, 1967). These authors also reported that transplanting rat uteri to the cheek pouch also reduced pseudopregnancy in hysterectomized hamsters (14\m=.\8days), whereas the effects of transplanting rabbit uteri (15\m=.\...

The small venules of the hamster cheek pouch were rendered susceptible to hemorrhage by total body x-irradiation, cheek pouch x-irradiation and beta emanations from strontium-90 glass beads imbedded in the cheek pouch, as determined by negative pressure and moccasin venom tests. Petechiae were formed without vessel rupture and ceased without formation of platelet plug or fibrin clot. Increased ...

The nitric oxide radical (*NO) released from tobacco-related compounds induces DNA damage, protein modifications, and cellular toxicity through the formation of peroxynitrite (ONOO-), the reaction product of *NO and the oxygen radical, superoxide. We hypothesize that tobacco-related compounds are cytotoxic and induce quantifiable DNA single-strand breaks in immortalized hamster cheek pouch (POI...

The anti-oxidant enzyme system protects cellular macromolecules against damage from reactive oxygen species. One component of this system, manganese superoxide dismutase (MnSOD), has also been shown to display tumor suppressor gene-like activity. The purpose of this study was to examine changes in MnSOD expression during hamster cheek pouch carcinogenesis, and the effects of MnSOD overexpressio...