Acinetobacter baumannii is an opportunistic gram-negative pathogen with increasing relevance in a variety of nosocomial infections especially among intensive-care-unit (ICU) patients. Carbapenems have been widely used to treat serious multidrug-resistant A. baumannii infections; however, incidences of carbapenem-resistant A. baumannii are rising in several parts of the world and large and susta...

ATLANTIS is the result of 8 years of experience with large standalone and smaller PCI based FPGA processors. Dedicated FPGA boards for computing and I/O plus a private backplane for a data rate of up to 1 GB/s support flexibility and scalability. FPGAs with more than 100k gates and 400 I/O pins per chip are used. CompactPCI provides the basic communication mechanism. Current real-time applicati...

Acinetobacter baumannii is currently one of the key nosocomial pathogens causing severe infections; of special concern is its resistance to expanded-spectrum cephalosporins (ESCs) and carbapenems, often associated with the few so-called European clones (6, 7, 19). It has two natural -lactamases, an AmpC-like enzyme (Acinetobacter-derived cephalosporinase [ADC]) (10) and a carbapenem-hydrolyzing...

Introducción: La preeclampsia-eclampsia es una de las principales causas morbimortalidad materna y perinatal. Objetivos: Determinar el riesgo aterogénico en la preeclampsia precoz tardía. Método: Estudio descriptivo corte transversal gestantes que ingresaron hospital materno con diagnóstico agravada entre los años 2010 – 2019. muestra quedó constituida por 506 mujeres, se subdividieron (menos 3...

Acinetobacter baumannii is frequently associated with nosocomial infections, and its increasing resistance to carbapenems may significantly reduce the choice of effective antibiotics (2). Since the first description of a carbapenem-hydrolyzing class D -lactamase (CHDL), ARI-1 (renamed OXA-23), from a clinical isolate of A. baumannii in Scotland in 1995 (11), the corresponding blaOXA-23 gene has...

La analogía del síndrome metabólico de la obesidad común (idiopática) con el síndrome de Cushing, ha suscitado la hipótesis de que cierto grado de hipercortisolismo subyacería a la concurrencia de alteraciones metabólicas e hipertensión arterial del síndrome metabólico1. En efecto, una serie de parámetros indicadores del metabolismo del cortisol se correlacionan positivamente con componentes de...

In natural environments most bacteria live in multicellular structures called biofilms. These cell aggregates are enclosed in a self-produced polymeric extracellular matrix, which protects the cells, provides mechanical stability and mediates cellular cohesion and adhesion to surfaces. Although important advances were made in the identification of the genetic and extracellular factors required ...

OBJECTIVE The purpose of this study was to evaluate the impact of diabetes and periodontal disease in us-CRP, an inflammatory marker in patients with and without acute myocardial infarction (AMI). SUBJECTS AND METHODS A case-control study was conducted in 401 subjects aged between 30 and 75 years, living in Bogotá D.C. (Colombia). Patients arriving at the emergency room of the San Ignacio Uni...

A recent article by Higgins et al. reported the identification of a novel carbapenem-hydrolyzing class D -lactamase (CHDL), defined as OXA-143, in a carbapenem-resistant Acinetobacter baumannii strain isolated in Brazil in 2004 (5). This enzyme, which has 88% identity with OXA-40, is the first representative of a novel subgroup of CHDLs whose prevalence remains to be determined (5). In an attem...