About a decade ago a multiple myeloma patient demonstrated a complete response to a proteasome inhibitor Bortezomib. This case generated a lot of hopes, and after successful clinical trials Bortezomib was approved by FDA and became the drug of choice for this disease. A high sensitivity of multiple myeloma to proteasome inhibition is probably related to extensive production immunoglobulins by t...

Synonymous mutations, which alter an mRNA sequence but not the encoded protein sequence, has been found to long-timescale function of proteins, including specific activity enzymes and ability proteins form oligomers. It is unknown how synonymous mutations lead such changes in structure function, why these altered structures are fixed by proteostasis machinery. Here, we address this gap our know...

Insight into interplay of some molecular chaperones in a hill stream teleost, Barilius bendelisis under wide seasonal and diurnal thermal fluctuationsSaurabh Dewan,Yashpal Singh,JP Bhatt

Proteome stability is central to cellular function and the lifespan of an organism. This is apparent in muscle cells, where incorrect folding and assembly of the sarcomere contributes to disease and aging. Apart from the myosin-assembly factor UNC-45, the complete network of chaperones involved in assembly and maintenance of muscle tissue is currently unknown. To identify additional factors req...

Molecular chaperones are a family of proteins that highly conserved during phylogenesis [...]