Recalled childhood gender nonconformity (CGN) and adult traits—e.g., masculinity–femininity of occupational preferences (MF-Occ), self-ascribed masculinity– femininity (Self-MF), self-reported anxiety—were assessed in an ethnically diverse US convenience sample of California college students and gay pride attendees, including 238 heterosexual men, 127 gay men, 343 heterosexual women, and 197 le...

conclusions the diagnosis of thrombocytosis is not easy in all cases. the coexistence of anca and the immune complex in cgn may cause a severe inflammatory state, leading to extreme rt. the roles that the immune complex and anca play on the effect of the platelet count and function in cgn need further research. introduction we describe a female patient with extreme reactive thrombocytosis (rt) ...

Aim: to analyze the histological kidney features in patients with CGN and arterial hypertension (AH) and without it, to assess the relationship between serum CysC and NGAL and histological signs of glomerular and tubular kidney lesion in patients with CGN with saved renal function. Methods: eighty one patients with CGN were enrolled in the study. Blood samples for biomarkers were collected. The...

The common food additive carrageenan (CGN) predictably induces intestinal inflammation in animal models. Mechanisms of CGN-induced nuclear factor κB and interleukin-8 (IL-8) stimulation include an immune-mediated pathway involving toll-like receptor 4 (TLR4) and B-cell lymphoma/leukemia 10 (BCL10) and a reactive oxygen species (ROS)-mediated pathway. To determine how the structure of CGN contri...

PKCε, a DAG-dependent, Ca2+- independent kinase attenuates extent of fibrosis following tissue injury, suppresses apoptosis and promotes cell quiescence. In crescentic glomerulonephritis (CGN), glomerular epithelial cells (GEC) contribute to fibro-cellular crescent formation while they also transdifferentiate to a mesenchymal phenotype. The aim of this study was to assess PKCε expression in CGN...

Dr. Xavier Bosch, Servicio de Medicina Interna General, Unidad 1, Hospital Clínico y Provincial, Villarroel, 170, E-08036 Barcelona (Spain) Dear Sir, Nässberger et al. [1] have recently reported the occurrence of anti-neutrophil cytoplasmic autoantibodies (ANCA) in sera from patients with crescentic glomerulonephritis (CGN). Among 64 patients with this disease, ANCA were detected in 47 (73%). B...

This document specifies a framework to integrate a Network Address Translation (NAT) layer into an operator’s network to function as a Carrier-Grade NAT (also known as CGN or Large-Scale NAT). The CGN infrastructure will often form a NAT444 environment as the subscriber home network will likely also maintain a subscriber-side NAT function. Exhaustion of the IPv4 address pool is a major driver c...

In previous studies we have shown that p23, a member of the p24-family of small transmembrane proteins, is highly abundant in membranes of the cis-Golgi network (CGN), and is involved in sorting/trafficking in the early secretory pathway. In the present study, we have further investigated the role of p23 after ectopic expression. We found that ectopically expressed p23 folded and oligomerized p...

BACKGROUND Antineutrophil cytoplasmic antibody (ANCA)-associated crescentic glomerulonephritis (CGN) is a major cause of rapidly progressive glomerulonephritis (RPGN). ANCA-associated CGN is generally classified into pauci-immune RPGN, in which there are few or no immune complexes. CASE PRESENTATION A 78-year-old man presented with RPGN after a 7-year course of chronic proteinuria and hematur...

The regulation of Rho-family GTPases is crucial to direct the formation of cell-cell junctions and tissue barriers. Cingulin (CGN) and paracingulin (CGNL1) control RhoA activation in epithelial cells by interacting with RhoA guanidine exchange factors. CGNL1 depletion also inhibits Rac1 activation during junction assembly. Here we show that, unexpectedly, Madin-Darby canine kidney epithelial ce...