Cerebral perfusion temperatures during antegrade cerebral perfusion and their affect on cerebral metabolism and neurological outcomes are evaluated in this study. Young piglets were subjected to a period of hypothermic circulatory arrest at 20°C using alphastat pH management. Four study groups were then assigned to differing temperatures of selective cerebral perfusion. Lower perfusion temperat...

New technology and advances in extracorporeal bypass circuitry and surgical techniques have drastically improved outcomes in infants with congenital heart defects. Hypothermia with circulatory arrest has fallen out of favor in many institutions over the last decade in part from data implicating even short circulatory arrest times to long-term neurologic sequelae. Implementing continuous cerebra...

The purpose of this study was to evaluate collateral circulation by describing anterior cerebral artery and middle cerebral artery perfusion areas. Pairs of image sets spin labeled on the medial and lateral side were used. A pixel-by-pixel t test was performed, with blue gradation used to display lateral perfusion (ie, middle cerebral artery) and orange gradation for anterior cerebral artery pe...

We describe the use of a CT-based method of cerebral perfusion imaging, dynamic CT perfusion imaging, for the pre- and postprocedural assessment of cerebral blood flow in a patient with symptomatic middle cerebral artery occlusive disease who underwent balloon angioplasty with stent placement in the affected artery. Dynamic CT perfusion imaging represents a widely available and minimally invasi...

The brain has been considered an index organ for global tissue perfusion because of the physiological processes aimed at flow preservation to vital organs of the body[1].When cerebral perfusion is compromised, other organs are likely inadequately perfused as well. It would therefore be prudent to monitor cerebral perfusion based on the proposition that interventions aimed at its preservation wi...

Sex differences in the brain appear to play an important role in the prevalence and progression of various neuropsychiatric disorders, but to date little is known about the cerebral mechanisms underlying these differences. One widely reported finding is that women demonstrate higher cerebral perfusion than men, but the underlying cause of this difference in perfusion is not known. This study in...

Cerebral perfusion pressure was reduced by graded constricting of both carotid arteries in the anesthetized dogs, of which vertebral arteries were ligated bilaterally. Cerebral blood flow and cerebral metabolic rate of oxygen remained unchanged until cerebral perfusion pressure was lowered to about 50 mm.Hg, indicating that cerebral autoregulation was preserved normally in these animals. Despit...

Cerebral blood flow was measured by the intravenous xenon-133 technique at rest and during cerebral vasodilation with acetazolamide in 32 patients before and after uncomplicated carotid endarterectomy. The results were compared with the internal carotid artery perfusion pressure measured during surgery. A significant improvement in side-to-side cerebral blood flow asymmetry occurred in 6 patien...